Synthesis and characterization of well-defined, amphiphilic poly(N-isopropylacrylamide)- b-[2-hydroxyethyl methacrylate-poly(ϵ-caprolactone)]n graft copolymers by RAFT polymerization and macromonomer method

The well‐defined, thermosensitive and biodegradable graft copolymers, poly(N‐isopropylacrylamide)‐b‐[2‐hydroxyethyl methacrylate‐poly(ε‐caprolactone)]n (PNIPAAm‐b‐(HEMA‐PCL)n) (n = 3 or 9), were synthesized by combining reversible addition‐fragmentation chain transfer polymerization and macromonomer...

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Bibliographic Details
Published in:Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2007-11, Vol.45 (22), p.5354-5364
Main Authors: Zhu, Jing-Ling, Zhang, Xian-Zheng, Cheng, Han, Li, Yong-Yong, Cheng, Si-Xue, Zhuo, Ren-Xi
Format: Article
Language:English
Subjects:
Applied sciences
biodegradable
Biological and medical sciences
Exact sciences and technology
General pharmacology
graft copolymers
Medical sciences
micelles
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polymers with particular properties
Preparation, kinetics, thermodynamics, mechanism and catalysts
RAFT polymerization
thermoresponse
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Summary:The well‐defined, thermosensitive and biodegradable graft copolymers, poly(N‐isopropylacrylamide)‐b‐[2‐hydroxyethyl methacrylate‐poly(ε‐caprolactone)]n (PNIPAAm‐b‐(HEMA‐PCL)n) (n = 3 or 9), were synthesized by combining reversible addition‐fragmentation chain transfer polymerization and macromonomer method. The copolymers were able to self‐assemble into micelles in water with low critical micellar concentration and demonstrated temperature sensitivity with a lower critical solution temperature at around 36 °C. Transmission electron microscopy shows that the micelles exhibit a nanosized spherical morphology within a size range of 30–100 nm. The PNIPAAm‐b‐(HEMA‐PCL)3 copolymer exhibited biodegradation and low cytotoxicity. The paclitaxel‐loaded PNIPAAm‐b‐(HEMA‐PCL)3 micelles displayed thermosensitive controlled release behavior, which indicates potential as drug carriers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5354–5364, 2007 Well‐defined poly(N‐isopropylacrylamide)‐b‐[2‐hydroxyethyl methacrylate‐poly(ε‐caprolactone)]n (PNIPAAm‐b‐(HEMA‐PCL)n) (n = 3 or 9) graft copolymers were synthesized by RAFT polymerization and macromonomer method. Transmission electron microscopy shows that the micelles exhibit a nanosized spherical morphology within a size range of 30–100 nm. The paclitaxel‐loaded PNIPAAm‐b‐(HEMA‐PCL)3 micelles show temperature‐stimulated controlled release, which would find great potential as smart drug carriers.
ISSN:0887-624X
1099-0518
DOI:10.1002/pola.22280