Copper(I) Iodide-Catalyzed Perfluoroalkoxylation Reaction of Alkyl Halides

We report an efficient perfluoroalkoxylation reaction of alkyl halides catalyzed by copper­(I) iodide (CuI), which facilitates the simultaneous activation of both perfluoroalkoxide and alkyl halides. This methodology is tolerant of a wide range of functional groups and eliminates the need for costly...

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Bibliographic Details
Published in:Organic letters 2024-08, Vol.26 (34), p.7139-7143
Main Authors: Wu, Xiong, Le, Bingjun, Xiao, Wangchuan, Wu, Jingjing, Wu, Fanhong, Ma, Xiaoyu, Liu, Chao
Format: Article
Language:English
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Summary:We report an efficient perfluoroalkoxylation reaction of alkyl halides catalyzed by copper­(I) iodide (CuI), which facilitates the simultaneous activation of both perfluoroalkoxide and alkyl halides. This methodology is tolerant of a wide range of functional groups and eliminates the need for costly metal reagents. The reaction is conducted in a single step under mildly practical conditions.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c02428