Executive function and cortical thickness in biomarker aMCI

Memory deficits are the primary symptom in amnestic Mild Cognitive Impairment (aMCI); however, executive function (EF) deficits are common. The current study examined EF in aMCI based upon amyloid status (A+/A-) and regional atrophy in signature areas of Alzheimer's disease (AD).INTRODUCTIONMem...

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Published in:Applied neuropsychology. Adult 2024-08, p.1
Main Authors: Scarisbrick, David M, Keith, Cierra M, Vieira Ligo Teixeira, Camila, Mehta, Rashi I, Phelps, Holly E, Coleman, Michelle M, Ward, Melanie, Miller, Mark, Navia, Osvaldo, Pockl, Stephanie, Rajabalee, Nafiisah, Marano, Gary, Malone, Joseph, D'Haese, Pierre F, Rezai, Ali R, Wilhelmsen, Kirk, Haut, Marc W
Format: Article
Language:English
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Summary:Memory deficits are the primary symptom in amnestic Mild Cognitive Impairment (aMCI); however, executive function (EF) deficits are common. The current study examined EF in aMCI based upon amyloid status (A+/A-) and regional atrophy in signature areas of Alzheimer's disease (AD).INTRODUCTIONMemory deficits are the primary symptom in amnestic Mild Cognitive Impairment (aMCI); however, executive function (EF) deficits are common. The current study examined EF in aMCI based upon amyloid status (A+/A-) and regional atrophy in signature areas of Alzheimer's disease (AD).Participants included 110 individuals with aMCI (A+ = 66; A- = 44) and 33 cognitively healthy participants (HP). EF was assessed using four neuropsychological assessment measures. The cortical thickness of the AD signature areas was calculated using structural MRI data.METHODParticipants included 110 individuals with aMCI (A+ = 66; A- = 44) and 33 cognitively healthy participants (HP). EF was assessed using four neuropsychological assessment measures. The cortical thickness of the AD signature areas was calculated using structural MRI data.A + had greater EF deficits and cortical atrophy relative to A - in the supramarginal gyrus and superior parietal lobule. A - had greater EF deficits relative to HP, but no difference in signature area cortical thickness.RESULTSA + had greater EF deficits and cortical atrophy relative to A - in the supramarginal gyrus and superior parietal lobule. A - had greater EF deficits relative to HP, but no difference in signature area cortical thickness.The current study found that the degree of EF deficits in aMCI are a function of amyloid status and cortical thinning in the parietal cortex.DISCUSSIONThe current study found that the degree of EF deficits in aMCI are a function of amyloid status and cortical thinning in the parietal cortex.
ISSN:2327-9109
2327-9109
DOI:10.1080/23279095.2024.2389255