Sperm chromatin dispersion assay reliability and assisted reproductive technology outcomes: Systematic review and meta-analysis

Elevated sperm DNA fragmentation has potential implications for semen quality and fertility. The commonly used sperm chromatin dispersion test offers an indirect estimation but has limitations in terms of bias and variability. This study aimed to assess the reliability of the sperm chromatin dispers...

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Bibliographic Details
Published in:Andrology (Oxford) 2024-08
Main Authors: Kaiyal, Raneen Sawaid, Karna, Keshab Kumar, Kuroda, Shinnosuke, Sgayer, Inshirah, Shlush, Ekaterina, Vij, Sarah C, Lundy, Scott D, Cannarella, Rossella
Format: Article
Language:English
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Summary:Elevated sperm DNA fragmentation has potential implications for semen quality and fertility. The commonly used sperm chromatin dispersion test offers an indirect estimation but has limitations in terms of bias and variability. This study aimed to assess the reliability of the sperm chromatin dispersion assay for predicting assisted reproductive technology outcomes. This systematic review included studies published until December 2023 that adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed/MEDLINE, Scopus, and Google Scholar databases were searched. Various assisted reproductive technology outcomes in patients with high (≥ 30%) versus low (
ISSN:2047-2919
2047-2927
2047-2927
DOI:10.1111/andr.13725