Comparing the effects of various fluid resuscitative strategies on Glycocalyx damage in a canine hemorrhage model

Hemorrhagic shock and subsequent resuscitation can cause significant dysregulation of critical systems, including the vascular endothelium. Following hemorrhage, the endothelial lining (glycocalyx) can shed, causing release of glycocalyx components, endothelial activation, and systemic inflammation....

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Bibliographic Details
Published in:The veterinary journal (1997) 2024-10, Vol.307, p.106221, Article 106221
Main Authors: Weaver, Alan J., Venn, Emilee C., Ford, Rebekah, Ewer, Nicole, Hildreth, Kim E., Williams, Charnae E., Duncan, Christina E., Calhoun, Cheresa L., Grantham, Lonnie E., Hoareau, Guillaume L., Edwards, Thomas H.
Format: Article
Language:English
Subjects:
Canine Hemorrhage
Glycocalyx
Resuscitation
Syndecan-1
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Summary:Hemorrhagic shock and subsequent resuscitation can cause significant dysregulation of critical systems, including the vascular endothelium. Following hemorrhage, the endothelial lining (glycocalyx) can shed, causing release of glycocalyx components, endothelial activation, and systemic inflammation. A canine model of hemorrhagic shock was used to evaluate five resuscitation fluids, including Lactated Ringers+Hetastarch, Whole Blood (WB), Fresh Frozen Plasma+packed Red Blood Cells (FFP+pRBC), and two hemoglobin-based oxygen carrier (HBOC) fluids, for their impact on glycocalyx shedding. Under anesthesia, purpose-bred adult canines were instrumented and subjected to a controlled hemorrhage with blood being drawn until a mean arterial pressure of
ISSN:1090-0233
1532-2971
1532-2971
DOI:10.1016/j.tvjl.2024.106221