Comparative Evaluation of the Radioprotective Properties of Copper Chlorophyllin, Trolox, and Indralin in an Experiment on Mice

The radioprotective properties of copper chlorophyllin (100 and 150 μg/g), the standard antioxidant trolox (100 and 200 μg/g), and the standard radioprotector indralin (100 and 150 μg/g) were compared in male ICR mice (CD-1) subjected to whole-body irradiation (X-ray radiation) in doses of 6, 6.5, a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-07, Vol.177 (3), p.328-332
Main Authors: Romodin, L. A., Nikitenko, O. V., Bychkova, T. M., Zrilova, Yu.A., Rodionova, E. D., Bocharov, D. A.
Format: Article
Language:English
Subjects:
Antioxidants
Biomedical and Life Sciences
Biomedicine
Body weight
Cell Biology
Chlorophyllin
Copper
Drug dosages
Experiments
Internal Medicine
Laboratory animals
Laboratory Medicine
Medical research
Pathology
Radiation
Toxicity
Vitamin E
X-rays
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Summary:The radioprotective properties of copper chlorophyllin (100 and 150 μg/g), the standard antioxidant trolox (100 and 200 μg/g), and the standard radioprotector indralin (100 and 150 μg/g) were compared in male ICR mice (CD-1) subjected to whole-body irradiation (X-ray radiation) in doses of 6, 6.5, and 6.75 Gy. Animal survival was analyzed using the Kaplan—Meier method, and the significance of differences was evaluated using the log-rank test method. Dose change factors determined using the Phinney probit analysis were 1.1, 1.0, and 1.8 for chlorophyllin, trolox, and indralin at a dose of 100 μg/g body weight, respectively. The insignificant radioprotective properties of chlorophyllin and their absence in trolox when administered prophylactically do not rule out their possible radioprotective properties like a radiomodulator that protects the body after irradiation.
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06183-z