Liver Transplantation for Benign Massive Hepatomegaly: Results From a Single Center and Contribution of the Left-to-Right Piggyback Approach

•Benign massive hepatomegaly with quality of life impairment symptoms may be an indication of liver transplantation.•Polycystic liver disease and giant hemangioma are the most common etiologies.•Performing total hepatectomy of enlarged livers is challenging.•The left-to-right piggyback approach is a...

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Published in:Transplantation proceedings 2024-06, Vol.56 (5), p.1098-1103
Main Authors: Vieira, Igor Ferreira, Waisberg, Daniel Reis, Rocha-Santos, Vinicius, Pinheiro, Rafael Soares, Martino, Rodrigo Bronze, Ducatti, Liliana, Arantes, Rubens Macedo, Nacif, Lucas Souto, Lee, Andre Dong, Haddad, Luciana Bertocco, Song, Alice Tung, Marin-Castro, Pedro, Alvarez, Jhosimar, Silva, Maciana Santos, Almeida, Juliani Dourado, Galvão, Flavio Henrique, Carneiro-D´Albuquerque, Luiz Augusto, Andraus, Wellington
Format: Article
Language:English
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Summary:•Benign massive hepatomegaly with quality of life impairment symptoms may be an indication of liver transplantation.•Polycystic liver disease and giant hemangioma are the most common etiologies.•Performing total hepatectomy of enlarged livers is challenging.•The left-to-right piggyback approach is a useful technique in this situation.•Previous liver cysts manipulation may lead to massive abdominal adhesions and increased bleeding in polycystic liver disease. Polycystic liver disease and giant hepatic hemangioma may present with severe symptom burden and indicate orthotopic liver transplantation. The left-to-right piggyback approach is a useful technique for performing total hepatectomy of enlarged livers. The purpose of this study is to analyze the results of liver transplantation in patients with benign massive hepatomegaly. This is a single-center retrospective study involving all adult patients who underwent liver transplantation due to benign massive hepatomegaly from January 2002 to June 2023. A total of 22 patients underwent liver transplantation (21 cases of polycystic live disease and 1 case of giant hepatic hemangioma). During the same time, there were 2075 transplants; therefore, benign massive hepatomegaly accounted for 1.06% of cases. Most patients (59.09%) were transplanted using the left-to-right piggyback technique. Seven patients had previous attempted treatment of hepatic cysts. Another patient previously underwent bilateral nephrectomy and living-donor kidney transplantation. Among these patients, in 5 cases there were massive abdominal adhesions with increased bleeding. Four of these 8 patients died in the very early perioperative period. In comparison to patients without previous cysts manipulation, massive adhesions and perioperative death were significantly higher in those cases (62.5 vs 0%, P = .002 and 50% vs 0%, P = .004, respectively). Liver transplantation due to polycystic liver disease and giant hemangioma is a rare event. Total hepatectomy is challenging due to the enlarged native liver. The left-to-right piggyback technique is useful, because it avoids vena cava twisting and avulsion of its branches. Massive adhesions due to previous cysts manipulation may lead to increased bleeding, being a risk factor for mortality.
ISSN:0041-1345
1873-2623
1873-2623
DOI:10.1016/j.transproceed.2024.05.002