Association between skeletal muscle mass and treatment response in patients with diffuse large B-cell lymphoma

Previous studies have demonstrated that a low skeletal muscle mass (SMM) is an adverse factor for overall survival (OS) in diffuse large B-cell lymphoma (DLBCL). However, its association with the treatment response has not been extensively investigated. This study aimed to determine the association...

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Bibliographic Details
Published in:Leukemia & lymphoma 2024-08, p.1-10
Main Authors: Sosa-Romero, Junice Teresita, Castillo-Martínez, Lilia, Gabutti-Thomas, Jesús Alejandro, Agreda-Vásquez, Gladys Patricia
Format: Article
Language:English
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Summary:Previous studies have demonstrated that a low skeletal muscle mass (SMM) is an adverse factor for overall survival (OS) in diffuse large B-cell lymphoma (DLBCL). However, its association with the treatment response has not been extensively investigated. This study aimed to determine the association between low skeletal muscle mass (SMM) and treatment response in DLBCL patients. We conducted a retrospective cohort study of 123 patients with DLBCL, in whom SMM was assessed using computed tomography before chemotherapy administration. The demographic characteristics of the patients with low SMM and those with normal SMM were not statistically different. However, there were notable differences in weight and BMI; patients with low SMM had a lower mean weight (59.2 vs 63, p = 0.002) and a higher proportion of patients with normal BMI (61.5% vs. 21.1%, p 
ISSN:1042-8194
1029-2403
1029-2403
DOI:10.1080/10428194.2024.2386591