Antiproliferative effect of low-level laser/ photobiomodulation on gingival fibroblasts derived from calcium channel blocker-induced gingival overgrowth

The aim of this study was to evaluate the antiproliferative properties of low-level laser therapy (LLLT) on gingival fibroblasts obtained from calcium channel blocker-induced gingival overgrowth (GO). Gingival fibroblasts of patients with GO were compared to healthy gingival fibroblasts (H). Both ce...

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Bibliographic Details
Published in:Lasers in medical science 2024-07, Vol.39 (1), p.194, Article 194
Main Authors: slezovic, Melis özgül, Saygun, Işıl, Bengi, Vahdi Umut, Serdar, Muhittin, Kantarci, Alpdogan
Format: Article
Language:English
Subjects:
Antiproliferatives
Calcium
Calcium channel blockers
Calcium channels
Cell proliferation
Collagen
Collagen (type I)
Connective tissue growth factor
Dentistry
Enzyme-linked immunosorbent assay
Fibroblasts
Gingiva
Growth factors
Lasers
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Photonics
Quantum Optics
Semiconductor lasers
Transforming growth factor-b
Transforming growth factor-b1
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Summary:The aim of this study was to evaluate the antiproliferative properties of low-level laser therapy (LLLT) on gingival fibroblasts obtained from calcium channel blocker-induced gingival overgrowth (GO). Gingival fibroblasts of patients with GO were compared to healthy gingival fibroblasts (H). Both cells were exposed to LLLT (685 nm wavelength, 25mW power, diode laser) and compared to those not treated with LLLT. Cell proliferation and viability were measured with MTT assay at baseline and after 24 and 72 h. TGF-β1, CTGF, and collagen Type 1 levels were evaluated with Enzyme-Linked Immunosorbent Assay (ELISA). LLLT significantly decreased the proliferation of GO fibroblasts ( p  
ISSN:1435-604X
0268-8921
1435-604X
DOI:10.1007/s10103-024-04122-y