Temperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest

Temperature control trials in cardiac arrest patients have not reliably conferred neuroprotective benefit but have been limited by inconsistent treatment parameters. To evaluate the presence of a time dependent treatment effect, we assessed the association between preinduction time and clinical outc...

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Bibliographic Details
Published in:Annals of emergency medicine 2024-07
Main Authors: Beekman, Rachel, Kim, Noah, Nguyen, Christine, McGinniss, George, Deng, Yanhong, Kitlen, Eva, Garcia, Gabriella, Wira, Charles, Khosla, Akhil, Johnson, Jennifer, Miller, P. Elliott, Perman, Sarah M., Sheth, Kevin N., Greer, David M., Gilmore, Emily J.
Format: Article
Language:English
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Summary:Temperature control trials in cardiac arrest patients have not reliably conferred neuroprotective benefit but have been limited by inconsistent treatment parameters. To evaluate the presence of a time dependent treatment effect, we assessed the association between preinduction time and clinical outcomes. In this retrospective, single academic center study between 2014 and 2022, consecutive out-of-hospital cardiac arrest (OHCA) patients treated with temperature control were identified. Preinduction was defined as the time from hospital arrival to initiation of a closed-loop temperature feedback device [door to temperature control initiation time], and early door to temperature control device time was defined a priori as
ISSN:0196-0644
1097-6760
1097-6760
DOI:10.1016/j.annemergmed.2024.06.007