TTV and CMV viral load dynamics: Which emerges first during immunosuppression?

Novel biomarkers reflecting the degree of immunosuppression in transplant patients are required to ensure eventual personalized equilibrium between rejection and infection risks. With the above aim, Torque Teno Virus (TTV) viremia was precisely examined in a large cohort of transplanted immunocompro...

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Bibliographic Details
Published in:Journal of medical virology 2024-07, Vol.96 (7), p.e29814-n/a
Main Authors: Roberto, Piergiorgio, Cinti, Lilia, Lucente, Dario, Russo, Gianluca, Lai, Quirino, Micozzi, Alessandra, Gentile, Giuseppe, Turriziani, Ombretta, Pierangeli, Alessandra, Antonelli, Guido
Format: Article
Language:English
Subjects:
Biomarker
Biomarkers
Cytomegalovirus
Cytomegalovirus (CMV)
Graft rejection
Health risks
Hematology
Immunocompromised hosts
Immunosuppression
Immunosuppressive agents
Infections
Peripheral blood
SOT
Torque Teno Virus (TTV)
Transplants & implants
Viremia
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Summary:Novel biomarkers reflecting the degree of immunosuppression in transplant patients are required to ensure eventual personalized equilibrium between rejection and infection risks. With the above aim, Torque Teno Virus (TTV) viremia was precisely examined in a large cohort of transplanted immunocompromised patients (192 hematological and 60 solid organ transplant recipients) being monitored for Cytomegalovirus reactivation. TTV load was measured in 2612 plasma samples from 448 patients. The results revealed a significant increase in TTV viral load approximately 14 days following CMV reactivation/infection in solid organ transplant (SOT) patients. No recognizable difference in TTV load was noted among hematological patients during the entire timeframe analyzed. Furthermore, a temporal gap of approximately 30 days was noted between the viral load peaks reached by the two viruses, with Cytomegalovirus (CMV) preceding TTV. It was not possible to establish a correlation between CMV reactivation/infection and TTV viremia in hematological patients. On the other hand, the SOT patient cohort allowed us to analyze viral kinetics and draw intriguing conclusions. Taken together, the data suggest, to our knowledge for the first time, that CMV infection itself could potentially cause an increase in TTV load in the peripheral blood of patients undergoing immunosuppressive therapy.
ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.29814