Nonsteroidal Anti‐Inflammatory Drugs and Experimental Chagas Disease: An Unsolved Question

ABSTRACT Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is not observable, but cardiac and gastrointestinal consequences are possible. Mice are the principal host used in ex...

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Bibliographic Details
Published in:Parasite immunology 2024-07, Vol.46 (7), p.e13057-n/a
Main Authors: Nicolau, Scheila Thaís, Tres, Daniela Patrícia, Ayala, Thaís Soprani, Menolli, Rafael Andrade
Format: Article
Language:English
Subjects:
Blood parasites
Chagas disease
Chronic infection
Coronary artery disease
Eicosanoids
Heart diseases
Immunosuppression
Immunosuppressive agents
Infections
lipidic mediators
Nonsteroidal anti-inflammatory drugs
NSAIDs
Parasitemia
Parasitic diseases
Pathogenesis
Prostaglandins
Protozoa
Trypanosoma cruzi
Trypanosoma cruzi infection
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Summary:ABSTRACT Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is not observable, but cardiac and gastrointestinal consequences are possible. Mice are the principal host used in experimental Chagas disease but reproduce the human infection depending on the animal and parasite strain, besides dose and route of administration. Lipidic mediators are tremendously involved in the pathogenesis of T. cruzi infection, meaning the prostaglandins and thromboxane, which participate in the immunosuppression characteristic of the acute phase. Thus, the eicosanoids inhibition caused by the nonsteroidal anti‐inflammatory drugs (NSAIDs) alters the dynamic of the disease in the experimental models, both in vitro and in vivo, which can explain the participation of the different mediators in infection. However, marked differences are founded in the various NSAIDs existing because of the varied routes blocked by the drugs. So, knowing the results in the experimental models of Chagas disease with or without the NSAIDs helps comprehend the pathogenesis of this infection, which still needs a better understanding.
ISSN:0141-9838
1365-3024
1365-3024
DOI:10.1111/pim.13057