Antibody levels against respiratory syncytial virus fusion protein conformations and lack of association with life-threatening infection in previously healthy infants

•RSV F-specific antibodies did not correlate with protection against life-threatening RSV disease in infants.•Pre-existing acute RSV neutralizing antibodies did not correlate with protection against life-threatening RSV disease.•Acute RSV F-specific antibodies negatively correlated with patient age....

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Bibliographic Details
Published in:Vaccine 2024-11, Vol.42 (25), p.126119, Article 126119
Main Authors: Bonnin, Florencia A., Talarico, Laura B., Ferolla, Fausto M., Acosta, Patricio L., Phung, Emily, Kumar, Azad, Toledano, Analía, Caratozzolo, Ana, Neira, Pablo, Mascardi, Normando, Satragno, Daniela, Contrini, María M., Graham, Barney S., Ruckwardt, Tracy J., López, Eduardo L.
Format: Article
Language:English
Subjects:
Age
Antibodies
Antibody response
Competition
Convalescence
Correlation
F protein
Fusion protein
Hospitalization
Immune response
Immune response (humoral)
Immune system
Immunoassays
Immunoglobulin G
Infants
Infections
Life-threatening respiratory syncytial virus disease
Monoclonal antibodies
Neutralization
Neutralizing
Neutralizing activity
Patients
Post-fusion protein
Pre-fusion protein
Protein structure
Proteins
Regression analysis
Respiratory syncytial virus
Severity
Vaccines
Viruses
Citations: Items that this one cites
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Description
Summary:•RSV F-specific antibodies did not correlate with protection against life-threatening RSV disease in infants.•Pre-existing acute RSV neutralizing antibodies did not correlate with protection against life-threatening RSV disease.•Acute RSV F-specific antibodies negatively correlated with patient age.•Convalescent RSV F-specific antibodies positively correlated with patient age for children over 2 months of age.•Acute RSV antibody titers showed no association with nasal RSV load. Humoral immune response against the pre-fusion (pre-F) conformation of respiratory syncytial virus (RSV) F protein has been proposed to play a protective role against infection. An RSV pre-F maternal vaccine has been recently approved in several countries to protect young infants against RSV. We aimed to assess serum IgG titers against the pre-F and post-F conformations of RSV F protein and their association with life-threatening RSV disease (LTD) in previously healthy infants. A prospective cohort study including hospitalized infants
ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2024.07.020