Successful intrahepatic cholangiocarcinoma conversion surgery after administration of fibroblast growth factor receptor inhibitor

Abstract We describe a case of a 47-year-old male patient with initially unresectable intrahepatic cholangiocarcinoma of the right liver lobe with tumor thrombi extending from the right bile duct to the common and left bile ducts. Conventional chemotherapy with gemcitabine and cisplatin for 19 month...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2024-07
Main Authors: Kaneko, Junichi, Kiuchi, Ryota, Takinami, Masaki, Ohnishi, Ippei, Ito, Jun, Jindo, Osamu, Nishino, Masafumi, Takahashi, Yurimi, Yamada, Takanori, Sakaguchi, Takanori
Format: Article
Language:English
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Summary:Abstract We describe a case of a 47-year-old male patient with initially unresectable intrahepatic cholangiocarcinoma of the right liver lobe with tumor thrombi extending from the right bile duct to the common and left bile ducts. Conventional chemotherapy with gemcitabine and cisplatin for 19 months resulted in progressive disease. Subsequently, a comprehensive genome profile revealed fibroblast growth factor receptor 2 rearrangement, and hence, pemigatinib administration was initiated. After 6 months of pemigatinib therapy, significant shrinking of the tumor and disappearance of the tumor thrombi in the common and left bile duct were observed. Subsequently, the patient underwent conversion surgery, resulting in successful radical resection of the tumor. The patient has been disease-free for 7 months.
ISSN:1865-7257
1865-7265
1865-7265
DOI:10.1007/s12328-024-02014-w