The effect of exercise and educational programs for breast cancer patients on the development of breast cancer-related lymphoedema: secondary endpoint from a randomized controlled trial in the Setouchi Breast Project-10

Background Although the association between higher physical activity and preventive effect on breast-cancer-related lymphoedema (BCRL) has been reported, it is unclear what intervention is optimal. We aimed to investigate the effect of exercise and educational programs on BCRL development. Methods T...

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Published in:Breast cancer (Tokyo, Japan) Japan), 2024-09, Vol.31 (5), p.969-978
Main Authors: Nakamoto, Shogo, Iwamoto, Takayuki, Taira, Naruto, Kajiwara, Yukiko, Kawada, Kengo, Takabatake, Daisuke, Miyoshi, Yuichiro, Kubo, Shinichiro, Suzuki, Yoko, Yamamoto, Mari, Ogasawara, Yutaka, Hatono, Minami, Yoshitomi, Seiji, Hara, Kyoko, Sasahara, Asako, Ohsumi, Shozo, Ikeda, Masahiko, Doihara, Hiroyoshi, Mizota, Yuri, Yamamoto, Seiichiro, Shien, Tadahiko, Toyooka, Shinichi
Format: Article
Language:English
Subjects:
Cancer Research
Medicine
Medicine & Public Health
Oncology
Original Article
Surgery
Surgical Oncology
UMIN
UMIN000020595
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Summary:Background Although the association between higher physical activity and preventive effect on breast-cancer-related lymphoedema (BCRL) has been reported, it is unclear what intervention is optimal. We aimed to investigate the effect of exercise and educational programs on BCRL development. Methods This study was a secondary endpoint analysis from a prospective randomized controlled trial. We enrolled patients with stage 0–III breast cancer from March 2016 to March 2020 and randomly assigned them to the control ( n  = 111), education ( n  = 115), or exercise ( n  = 104) group. As secondary endpoint, we assessed the incidence of and preventive effect on BCRL at 12 months post-intervention. Results There were no significant differences in the incidence of BCRL at 12 months post-intervention between the exercise and control groups (9.8% and 10.8%, P  = 0.83) and the education and control groups (11.6% and 10.8%, P  = 1.00). There were no significant differences in time to BCRL onset from the day of surgery between the exercise and control groups (event rate at 12 months: 20.7% and 17.2%, log-rank, P  = 0.54) and the education and control groups (18.8% and 17.2%, log-rank, P  = 0.57). The multivariable analyses indicated that axillary dissection and obesity significantly increased the risk of BCRL [hazard ratio (HR): 2.36, 95% confidence interval (CI) 1.52–3.67 and HR: 1.68, 95% CI 1.07–2.63, respectively]. Conclusions The intervention did not decrease the risk of BCRL, and axillary dissection and obesity were the risk factors of BCRL. Trial registration number UMIN000020595 at UMIN Clinical Trial Registry.
ISSN:1340-6868
1880-4233
1880-4233
DOI:10.1007/s12282-024-01610-5