2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases

Objective We provide evidence‐based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs). Methods We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature...

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Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2024-08, Vol.76 (8), p.1182-1200
Main Authors: Johnson, Sindhu R., Bernstein, Elana J., Bolster, Marcy B., Chung, Jonathan H., Danoff, Sonye K., George, Michael D., Khanna, Dinesh, Guyatt, Gordon, Mirza, Reza D., Aggarwal, Rohit, Allen, Aberdeen, Assassi, Shervin, Buckley, Lenore, Chami, Hassan A., Corwin, Douglas S., Dellaripa, Paul F., Domsic, Robyn T., Doyle, Tracy J., Falardeau, Catherine Marie, Frech, Tracy M., Gibbons, Fiona K., Hinchcliff, Monique, Johnson, Cheilonda, Kanne, Jeffrey P., Kim, John S., Lim, Sian Yik, Matson, Scott, McMahan, Zsuzsanna H., Merck, Samantha J., Nesbitt, Kiana, Scholand, Mary Beth, Shapiro, Lee, Sharkey, Christine D., Summer, Ross, Varga, John, Warrier, Anil, Agarwal, Sandeep K., Antin‐Ozerkis, Danielle, Bemiss, Bradford, Chowdhary, Vaidehi, Dematte D'Amico, Jane E., Hallowell, Robert, Hinze, Alicia M., Injean, Patil A., Jiwrajka, Nikhil, Joerns, Elena K., Lee, Joyce S., Makol, Ashima, McDermott, Gregory C., Natalini, Jake G., Oldham, Justin M., Saygin, Didem, Lakin, Kimberly Showalter, Singh, Namrata, Solomon, Joshua J., Sparks, Jeffrey A., Turgunbaev, Marat, Vaseer, Samera, Turner, Amy, Uhl, Stacey, Ivlev, Ilya
Format: Article
Language:English
Subjects:
Chest
Glucocorticoids
Health services
Literature reviews
Lung diseases
Physicians
Rheumatic diseases
Rheumatology
Systemic sclerosis
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Summary:Objective We provide evidence‐based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs). Methods We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations. Results Thirty‐five recommendations were generated (including two strong recommendations) for first‐line SARD‐ILD treatment, treatment of SARD‐ILD progression despite first‐line ILD therapy, and treatment of rapidly progressive ILD. The strong recommendations were against using glucocorticoids in systemic sclerosis–ILD as a first‐line ILD therapy and after ILD progression. Otherwise, glucocorticoids are conditionally recommended for first‐line ILD treatment in all other SARDs. Conclusion This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the treatment of ILD in people with SARDs.
ISSN:2326-5191
2326-5205
2326-5205
DOI:10.1002/art.42861