Exploring the antimicrobial and antioxidant potential of bacterial cellulose-cerium oxide nanoparticles hydrogel: Design, characterization and biomedical properties

Bacterial cellulose (BC) is a promising natural polymer prized for its biocompatibility, microporosity, transparency, conformability, elasticity, and ability to maintain a moist wound environment while absorbing exudates. These attributes make BC an attractive material in biomedical applications, pa...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-09, Vol.276 (Pt 1), p.133702, Article 133702
Main Authors: Butulija, Svetlana, Šobot, Ana Valenta, Todorović, Bratislav, Petrović, Sanja M., Radovanović, Željko, Ilić, Bojana, Matović, Branko, Mihailović, Ružica, Zarubica, Aleksandra, Zmejkoski, Danica, Tričković, Jelena Filipović
Format: Article
Language:English
Subjects:
Antimicrobial activity
Antioxidant properties
Bacterial cellulose
Biocompatibility
Cerium oxide nanoparticles
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Summary:Bacterial cellulose (BC) is a promising natural polymer prized for its biocompatibility, microporosity, transparency, conformability, elasticity, and ability to maintain a moist wound environment while absorbing exudates. These attributes make BC an attractive material in biomedical applications, particularly in skin tissue repair. However, its lack of inherent antimicrobial activity limits its effectiveness. In this study, BC was enhanced by incorporating cerium (IV)-oxide (CeO2) nanoparticles, resulting in a series of bacterial cellulose-CeO2 (BC-CeO2) composite materials. Characterization via FESEM, XRD, and FTIR confirmed the successful synthesis of the composites. Notably, BC-CeO2-1 exhibited no cytotoxic or genotoxic effects on peripheral blood lymphocytes, and it additionally protected cells from genotoxic and cytotoxic effects in H2O2-treated cultures. Redox parameters in blood plasma samples displayed concentration and time-dependent trends in PAB and LPP assays. The incorporation of CeO2 nanoparticles also bolstered antimicrobial activity, expanding the potential biomedical applications of these composites. •Successful reinforcement of BC with CeO2 nanoparticles•Interaction between CeO2 and BC•The potential to confine effects to a local level, minimizing systemic impact•BC-CeO2-1 demonstrates cyto/geno protective effects.•Antimicrobial efficacy highlights BC-CeO2's potential in wound care.
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.133702