Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival

Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous vali...

Full description

Saved in:
Bibliographic Details
Published in:Journal of surgical oncology 2024-07
Main Authors: Vaz da Silva, Diego Greatti, de Ribeiro, Heber Salvador de Castro, dos Santos, Gabriel Oliveira, Lindote, Marcus Vitor Nunes, Torres, Silvio Mello, Diniz, Alessandro Lansdskron, de Godoy, André Luiz, de Farias, Igor Correia, Felismino, Tiago Cordeiro, da Costa Junior, Wilson Luiz, Coimbra, Felipe José Fernández
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c152t-65bd18f7b3e0f79e9a06cee9788f24cdf72c90adcf7a98daaef4c4d4531720853
container_end_page
container_issue
container_start_page
container_title Journal of surgical oncology
container_volume
creator Vaz da Silva, Diego Greatti
de Ribeiro, Heber Salvador de Castro
dos Santos, Gabriel Oliveira
Lindote, Marcus Vitor Nunes
Torres, Silvio Mello
Diniz, Alessandro Lansdskron
de Godoy, André Luiz
de Farias, Igor Correia
Felismino, Tiago Cordeiro
da Costa Junior, Wilson Luiz
Coimbra, Felipe José Fernández
description Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous validation. The objective was to demonstrate the association between TILs and survival in patients with CRLM. Method In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides. Results This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease‐free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group ( p = 0.001), and DFS was 14 months versus 9 months ( p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031). Conclusions Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision‐making process for this group of patients.
doi_str_mv 10.1002/jso.27759
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3074135066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3074135066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c152t-65bd18f7b3e0f79e9a06cee9788f24cdf72c90adcf7a98daaef4c4d4531720853</originalsourceid><addsrcrecordid>eNotkM1KAzEQx4MoWKsH3yDH9rA12a9sjlK_CgUv9bxMsxNNyW5qkl3oTd_AZ_RJXK0wzPxhfgzDj5BrzhacsfRmF9wiFaKQJ2TCmSwTyWR1SibjLk1yIdk5uQhhxxiTsswn5PMOu4A09q3z3x9fptPGRg_RdK_UHtr9m1OHiIHONqt1mFPTUWsG9LTFCGEsE6j2rqXKWedRRbBUQadGAjxSjxYiNjQ6atq9d8OYx-bBWhp6P5gB7CU502ADXv3PKXl5uN8sn5L18-NqebtOFC_SmJTFtuGVFtsMmRYSJbBSIUpRVTrNVaNFqiSDRmkBsmoAUOcqb_Ii4yJlVZFNyex4d_zjvccQ69YEhdZCh64PdcZEzrOCleWIzo-o8i4Ej7ree9OCP9Sc1b-a61Fz_ac5-wFTHHTp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3074135066</pqid></control><display><type>article</type><title>Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival</title><source>Wiley Online Library</source><creator>Vaz da Silva, Diego Greatti ; de Ribeiro, Heber Salvador de Castro ; dos Santos, Gabriel Oliveira ; Lindote, Marcus Vitor Nunes ; Torres, Silvio Mello ; Diniz, Alessandro Lansdskron ; de Godoy, André Luiz ; de Farias, Igor Correia ; Felismino, Tiago Cordeiro ; da Costa Junior, Wilson Luiz ; Coimbra, Felipe José Fernández</creator><creatorcontrib>Vaz da Silva, Diego Greatti ; de Ribeiro, Heber Salvador de Castro ; dos Santos, Gabriel Oliveira ; Lindote, Marcus Vitor Nunes ; Torres, Silvio Mello ; Diniz, Alessandro Lansdskron ; de Godoy, André Luiz ; de Farias, Igor Correia ; Felismino, Tiago Cordeiro ; da Costa Junior, Wilson Luiz ; Coimbra, Felipe José Fernández</creatorcontrib><description>Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous validation. The objective was to demonstrate the association between TILs and survival in patients with CRLM. Method In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides. Results This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease‐free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group ( p = 0.001), and DFS was 14 months versus 9 months ( p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031). Conclusions Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision‐making process for this group of patients.</description><identifier>ISSN: 0022-4790</identifier><identifier>ISSN: 1096-9098</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.27759</identifier><language>eng</language><ispartof>Journal of surgical oncology, 2024-07</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c152t-65bd18f7b3e0f79e9a06cee9788f24cdf72c90adcf7a98daaef4c4d4531720853</cites><orcidid>0000-0003-4460-4706 ; 0000-0002-4085-2668 ; 0000-0002-3412-7451 ; 0000-0001-7274-3602</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Vaz da Silva, Diego Greatti</creatorcontrib><creatorcontrib>de Ribeiro, Heber Salvador de Castro</creatorcontrib><creatorcontrib>dos Santos, Gabriel Oliveira</creatorcontrib><creatorcontrib>Lindote, Marcus Vitor Nunes</creatorcontrib><creatorcontrib>Torres, Silvio Mello</creatorcontrib><creatorcontrib>Diniz, Alessandro Lansdskron</creatorcontrib><creatorcontrib>de Godoy, André Luiz</creatorcontrib><creatorcontrib>de Farias, Igor Correia</creatorcontrib><creatorcontrib>Felismino, Tiago Cordeiro</creatorcontrib><creatorcontrib>da Costa Junior, Wilson Luiz</creatorcontrib><creatorcontrib>Coimbra, Felipe José Fernández</creatorcontrib><title>Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival</title><title>Journal of surgical oncology</title><description>Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous validation. The objective was to demonstrate the association between TILs and survival in patients with CRLM. Method In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides. Results This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease‐free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group ( p = 0.001), and DFS was 14 months versus 9 months ( p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031). Conclusions Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision‐making process for this group of patients.</description><issn>0022-4790</issn><issn>1096-9098</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNotkM1KAzEQx4MoWKsH3yDH9rA12a9sjlK_CgUv9bxMsxNNyW5qkl3oTd_AZ_RJXK0wzPxhfgzDj5BrzhacsfRmF9wiFaKQJ2TCmSwTyWR1SibjLk1yIdk5uQhhxxiTsswn5PMOu4A09q3z3x9fptPGRg_RdK_UHtr9m1OHiIHONqt1mFPTUWsG9LTFCGEsE6j2rqXKWedRRbBUQadGAjxSjxYiNjQ6atq9d8OYx-bBWhp6P5gB7CU502ADXv3PKXl5uN8sn5L18-NqebtOFC_SmJTFtuGVFtsMmRYSJbBSIUpRVTrNVaNFqiSDRmkBsmoAUOcqb_Ii4yJlVZFNyex4d_zjvccQ69YEhdZCh64PdcZEzrOCleWIzo-o8i4Ej7ree9OCP9Sc1b-a61Fz_ac5-wFTHHTp</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Vaz da Silva, Diego Greatti</creator><creator>de Ribeiro, Heber Salvador de Castro</creator><creator>dos Santos, Gabriel Oliveira</creator><creator>Lindote, Marcus Vitor Nunes</creator><creator>Torres, Silvio Mello</creator><creator>Diniz, Alessandro Lansdskron</creator><creator>de Godoy, André Luiz</creator><creator>de Farias, Igor Correia</creator><creator>Felismino, Tiago Cordeiro</creator><creator>da Costa Junior, Wilson Luiz</creator><creator>Coimbra, Felipe José Fernández</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4460-4706</orcidid><orcidid>https://orcid.org/0000-0002-4085-2668</orcidid><orcidid>https://orcid.org/0000-0002-3412-7451</orcidid><orcidid>https://orcid.org/0000-0001-7274-3602</orcidid></search><sort><creationdate>202407</creationdate><title>Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival</title><author>Vaz da Silva, Diego Greatti ; de Ribeiro, Heber Salvador de Castro ; dos Santos, Gabriel Oliveira ; Lindote, Marcus Vitor Nunes ; Torres, Silvio Mello ; Diniz, Alessandro Lansdskron ; de Godoy, André Luiz ; de Farias, Igor Correia ; Felismino, Tiago Cordeiro ; da Costa Junior, Wilson Luiz ; Coimbra, Felipe José Fernández</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c152t-65bd18f7b3e0f79e9a06cee9788f24cdf72c90adcf7a98daaef4c4d4531720853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaz da Silva, Diego Greatti</creatorcontrib><creatorcontrib>de Ribeiro, Heber Salvador de Castro</creatorcontrib><creatorcontrib>dos Santos, Gabriel Oliveira</creatorcontrib><creatorcontrib>Lindote, Marcus Vitor Nunes</creatorcontrib><creatorcontrib>Torres, Silvio Mello</creatorcontrib><creatorcontrib>Diniz, Alessandro Lansdskron</creatorcontrib><creatorcontrib>de Godoy, André Luiz</creatorcontrib><creatorcontrib>de Farias, Igor Correia</creatorcontrib><creatorcontrib>Felismino, Tiago Cordeiro</creatorcontrib><creatorcontrib>da Costa Junior, Wilson Luiz</creatorcontrib><creatorcontrib>Coimbra, Felipe José Fernández</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaz da Silva, Diego Greatti</au><au>de Ribeiro, Heber Salvador de Castro</au><au>dos Santos, Gabriel Oliveira</au><au>Lindote, Marcus Vitor Nunes</au><au>Torres, Silvio Mello</au><au>Diniz, Alessandro Lansdskron</au><au>de Godoy, André Luiz</au><au>de Farias, Igor Correia</au><au>Felismino, Tiago Cordeiro</au><au>da Costa Junior, Wilson Luiz</au><au>Coimbra, Felipe José Fernández</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival</atitle><jtitle>Journal of surgical oncology</jtitle><date>2024-07</date><risdate>2024</risdate><issn>0022-4790</issn><issn>1096-9098</issn><eissn>1096-9098</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous validation. The objective was to demonstrate the association between TILs and survival in patients with CRLM. Method In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides. Results This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease‐free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group ( p = 0.001), and DFS was 14 months versus 9 months ( p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031). Conclusions Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision‐making process for this group of patients.</abstract><doi>10.1002/jso.27759</doi><orcidid>https://orcid.org/0000-0003-4460-4706</orcidid><orcidid>https://orcid.org/0000-0002-4085-2668</orcidid><orcidid>https://orcid.org/0000-0002-3412-7451</orcidid><orcidid>https://orcid.org/0000-0001-7274-3602</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0022-4790
ispartof Journal of surgical oncology, 2024-07
issn 0022-4790
1096-9098
1096-9098
language eng
recordid cdi_proquest_miscellaneous_3074135066
source Wiley Online Library
title Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A25%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dense%20tumor%E2%80%90infiltrating%20lymphocytes%20(TILs)%20in%20liver%20metastasis%20from%20colorectal%20cancer%20are%20related%20to%20improved%20overall%20survival&rft.jtitle=Journal%20of%20surgical%20oncology&rft.au=Vaz%20da%20Silva,%20Diego%20Greatti&rft.date=2024-07&rft.issn=0022-4790&rft.eissn=1096-9098&rft_id=info:doi/10.1002/jso.27759&rft_dat=%3Cproquest_cross%3E3074135066%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c152t-65bd18f7b3e0f79e9a06cee9788f24cdf72c90adcf7a98daaef4c4d4531720853%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3074135066&rft_id=info:pmid/&rfr_iscdi=true