Dense tumor‐infiltrating lymphocytes (TILs) in liver metastasis from colorectal cancer are related to improved overall survival

Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous vali...

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Published in:Journal of surgical oncology 2024-07
Main Authors: Vaz da Silva, Diego Greatti, de Ribeiro, Heber Salvador de Castro, dos Santos, Gabriel Oliveira, Lindote, Marcus Vitor Nunes, Torres, Silvio Mello, Diniz, Alessandro Lansdskron, de Godoy, André Luiz, de Farias, Igor Correia, Felismino, Tiago Cordeiro, da Costa Junior, Wilson Luiz, Coimbra, Felipe José Fernández
Format: Article
Language:English
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Summary:Abstract Background and Objectives Tumor‐infiltrating lymphocytes (TILs) represent a host‐tumor interaction, frequently signifying an augmented immunological response. Nonetheless, implications with survival outcomes in patients with colorectal carcinoma liver metastasis (CRLM) warrant rigorous validation. The objective was to demonstrate the association between TILs and survival in patients with CRLM. Method In a retrospective evaluation conducted in a single institution, we assessed all patients who underwent hepatectomy due to CRLM between 2014 and 2018. Comprehensive medical documentation reviews were executed. TILs were assessed by a liver pathologist, blinded to the clinical information, in all surgical slides. Results This retrospective cohort included 112 patients. Median overall survival (OS) was 58 months and disease‐free survival (DFS) was 12 months for the entire cohort. Comparison between groups showed a median OS of 81 months in the dense TILs group and 40 months in the weak/absent group ( p = 0.001), and DFS was 14 months versus 9 months ( p = 0.041). Multivariable analysis showed that TILs were an independent predictor of OS (HR 1.95; p = 0.031). Conclusions Dense TILs are a pivotal prognostic indicator, correlating with enhanced OS. Including TILs information in histopathological evaluations should refine the clinical decision‐making process for this group of patients.
ISSN:0022-4790
1096-9098
1096-9098
DOI:10.1002/jso.27759