The effects of curcumin supplementation on biomarkers of inflammation, oxidative stress, and endothelial function: A meta-analysis of meta-analyses

Numerous interventional studies have revealed the beneficial impact of curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers, but the findings are still inconsistent. Thus, this study was conducted to investigate the effects of curcumin supplementation on in...

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Bibliographic Details
Published in:Prostaglandins & other lipid mediators 2024-10, Vol.174, p.106867, Article 106867
Main Authors: Kavyani, Zeynab, Najafi, Kianoosh, Naghsh, Navid, Karvane, Houshang Bavandpour, Musazadeh, Vali
Format: Article
Language:English
Subjects:
Blood pressure
Curcumin
Endothelial function
Inflammation
Oxidative stress
Umbrella review
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Summary:Numerous interventional studies have revealed the beneficial impact of curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers, but the findings are still inconsistent. Thus, this study was conducted to investigate the effects of curcumin supplementation on inflammation, oxidative stress, and endothelial function biomarkers. A meta-analyses of randomized clinical trials was performed by searching PubMed, Embase, Scopus, and Web of Science up to March 31, 2024. Pooled estimates of 21 meta-analyses revealed that curcumin significantly reduced CRP (weighted mean difference (WMD) = −0.87; 95 % CI: - 1.14, - 0.59, P< 0.001), tumor-necrosis factor-alpha (TNF-α) (WMD = −2.72; 95 % CI: −4.05, −1.38; P< 0.001), interleukin-6 (IL-6) (WMD = −0.97, 95 % CI: −1.40, −0.54; P< 0.001), malondialdehyde (MDA) (Effect size (ES) = −0.81; 95 % CI: −1.39, −0.23, P = 0.006) and pulse wave velocity (PWV) (WMD = −45.60; 95 % CI: −88.16, −3.04, P = 0.036), and increased flow-mediated dilation (FMD) (WMD = 1.64, 95 % CI: 1.06, 2.22, P < 0.001), catalase (CAT) (WMD = 10.26; 95 % CI: 0.92, 19.61, P= 0.03), glutathione peroxidase (GPx) (WMD = 8.90; 95 % CI: 6.62, 11.19, P
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2024.106867