Feasibility, safety, and efficacy of intraoperative magnetic resonance imaging-guided hepatectomy for small hepatocellular carcinoma: A retrospective study

Advancements in diagnostic modalities, such as enhanced magnetic resonance imaging, provide increased opportunities for identifying small hepatocellular carcinoma that is undetectable on preoperative ultrasonography. Whether it is acceptable to leave these lesions untreated is uncertain. This study...

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Bibliographic Details
Published in:PloS one 2024-06, Vol.19 (6), p.e0306307
Main Authors: Matsubara, Keiso, Kuroda, Shintaro, Kobayashi, Tsuyoshi, Ide, Kentaro, Tahara, Hiroyuki, Ohira, Masahiro, Honmyo, Naruhiko, Akiyama, Yuji, Tsuge, Masataka, Awai, Kazuo, Ohdan, Hideki
Format: Article
Language:English
Subjects:
Catheters
Cirrhosis
Diagnosis
Effectiveness
Electronics in navigation
Gadoxetate
Hepatectomy
Hepatitis
Hepatocellular carcinoma
Hepatoma
Lesions
Liver
Liver cancer
Liver cirrhosis
Magnetic resonance
Magnetic resonance imaging
Medical imaging
Navigation systems
Performance evaluation
Polyvinyl chloride
Prognosis
Surgery
Tumors
Ultrasound imaging
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Summary:Advancements in diagnostic modalities, such as enhanced magnetic resonance imaging, provide increased opportunities for identifying small hepatocellular carcinoma that is undetectable on preoperative ultrasonography. Whether it is acceptable to leave these lesions untreated is uncertain. This study aimed to evaluate the safety and efficacy of intraoperative magnetic resonance imaging-guided hepatectomy using new navigation systems. This study was conducted between July 2019 and January 2023. We retrospectively studied the clinicopathological features and prognoses of patients with small hepatocellular carcinoma who underwent curative intraoperative magnetic resonance imaging-guided hepatectomy. We evaluated 23 patients (median age, 75 years), among whom 20 (87.0%) were males. Seven (30.4%) and 15 (65.2%) patients had liver cirrhosis and a history of hepatectomy, respectively. The median size of the target lesions was 9 mm, with a median distance of 6 mm from the liver surface. Despite being undetectable preoperatively on contrast-enhanced ultrasonography, all lesions were identified using intraoperative magnetic resonance imaging. Based on pathological findings, 76.0% of the lesions were malignant. The complete resection rate was 100%, and tumor-free margins were confirmed in 96.0% of the patients. Intraoperative magnetic resonance imaging-guided hepatectomy is safe and effective in identifying and resecting small hepatocellular carcinoma lesions that are undetectable on preoperative ultrasonography.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0306307