Recent Advances on Sex Hormone‐Binding Globulin Regulation by Nutritional Factors: Clinical Implications

Sex hormone‐binding globulin (SHBG) is a homodimeric glycoprotein produced by the human liver and secreted into the systemic circulation where it binds with high affinity sex steroids regulating their availability in blood and accessibility to target tissues. Plasma SHBG levels are altered in metabo...

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Bibliographic Details
Published in:Molecular nutrition & food research 2024-07, Vol.68 (14), p.e2400020-n/a
Main Authors: Brianso‐Llort, Laura, Saéz‐Lopez, Cristina, Alvarez‐Guaita, Anna, Ramos‐Perez, Lorena, Hernandez, Cristina, Simó, Rafael, Selva, David M.
Format: Article
Language:English
Subjects:
Anorexia
Binding
Blood circulation
Blood levels
caffeine
carbohydrates
Diet
Eating disorders
Gene expression
Globulins
Glycoproteins
human disease
Insulin resistance
Liver
Liver diseases
Mediterranean diet
Metabolic disorders
Molecular modelling
Nutrient content
olive oil
red wine
Sex hormones
sex hormone‐binding globulin
Steroid hormones
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Summary:Sex hormone‐binding globulin (SHBG) is a homodimeric glycoprotein produced by the human liver and secreted into the systemic circulation where it binds with high affinity sex steroids regulating their availability in blood and accessibility to target tissues. Plasma SHBG levels are altered in metabolic disorders such as obesity, anorexia, and insulin resistance. Several reports have shown that diets in terms of total calories or fat, fiber, or protein content can alter plasma SHBG levels. However, there are many components in a diet that can affect SHBG gene expression in the liver. In order to unravel the molecular mechanisms by which diets regulate SHBG production, it would be necessary to analyze single diet components and/or nutritional factors. This review summarizes the recent advances in identifying different nutritional factors regulating SHBG production and the related molecular mechanism, as well as the clinical implications. Diet composition affects SHBG expression in the liver which in turn could have an effect on human disease development and/or progression.
ISSN:1613-4125
1613-4133
1613-4133
DOI:10.1002/mnfr.202400020