Liposomal curcumin inhibits cigarette smoke induced senescence and inflammation in human bronchial epithelial cells

Curcumin, the principal curcuminoid of turmeric (Curcuma longa extract), is very well known for its multiple biological therapeutic activities, particularly its anti-inflammatory and antioxidant potential. However, due to its low water solubility, it exhibits poor bioavailability. In order to overco...

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Published in:Pathology, research and practice research and practice, 2024-08, Vol.260, p.155423, Article 155423
Main Authors: Kokkinis, Sofia, De Rubis, Gabriele, Paudel, Keshav Raj, Patel, Vyoma K., Yeung, Stewart, Jessamine, Victoria, MacLoughlin, Ronan, Hansbro, Philip M., Oliver, Brian, Dua, Kamal
Format: Article
Language:English
Subjects:
Chronic Obstructive Pulmonary Disease
Curcumin
Liposomes
Nanoparticles
Phytoceuticals
PlexoZome
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Summary:Curcumin, the principal curcuminoid of turmeric (Curcuma longa extract), is very well known for its multiple biological therapeutic activities, particularly its anti-inflammatory and antioxidant potential. However, due to its low water solubility, it exhibits poor bioavailability. In order to overcome this problem, in the current study, we have employed liposomal technology to encapsulate curcumin with the aim of enhancing its therapeutic efficacy. The curcumin-loaded liposomes (PlexoZome®) were tested on a cigarette smoke extract-induced Chronic Obstructive Pulmonary Disease (COPD) in vitro model using minimally immortalized human bronchial epithelial cells (BCiNS1.1). The anti-senescence and anti-inflammatory properties of PlexoZome® were explored. 5 µM PlexoZome® curcumin demonstrated anti-senescent activity by decrease in X-gal positive cells, and reduction in the expression of p16 and p21 in immunofluorescence staining. Moreover, PlexoZome® curcumin also demonstrated a reduction in proteins related to senescence (osteopontin, FGF basic and uPAR) and inflammation (GM-CSF, EGF and ST2). Overall, the results clearly demonstrate the therapeutic potential of curcumin encapsulated liposomes in managing CSE induced COPD, providing a new direction to respiratory clinics.
ISSN:0344-0338
1618-0631
1618-0631
DOI:10.1016/j.prp.2024.155423