Activated AMP-protein kinase (pAMPK) is overexpressed in human somatotroph pituitary adenomas

AMPK (AMP-activated protein kinase) is an enzyme that acts as a metabolic sensor and regulates multiple pathways via phosphorylating proteins in metabolic and proliferative pathways. The aim of this work was to study the activated cellular AMPK (phosphorylated-AMPK at Thr172, pAMPK) levels in pituit...

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Published in:Molecular and cellular endocrinology 2024-10, Vol.592, p.112318, Article 112318
Main Authors: Bizzi, Mariana Ferreira, Drummond, Juliana Beaudette, Pinheiro, Sergio Veloso Brant, Paulino, Eduardo, Araújo, Stanley Almeida, Soares, Beatriz Santana, Giannetti, Alexandre V., Schweizer, Júnia Ribeiro de Oliveira Longo, Barry, Sayka, Korbonits, Márta, Ribeiro-Oliveira, Antonio
Format: Article
Language:English
Subjects:
Acromegaly
AIP
AMPK
CAM5.2
GNAS
Metformin
Mutation
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Summary:AMPK (AMP-activated protein kinase) is an enzyme that acts as a metabolic sensor and regulates multiple pathways via phosphorylating proteins in metabolic and proliferative pathways. The aim of this work was to study the activated cellular AMPK (phosphorylated-AMPK at Thr172, pAMPK) levels in pituitary tumor samples from patients with sporadic and familial acromegaly, as well as in samples from normal human pituitary gland. We studied pituitary adenoma tissue from patients with sporadic somatotroph adenomas, familial acromegaly with heterozygote germline variants in the aryl hydrocarbon receptor interacting protein (AIP) gene (p.Q164*, p.R304* and p.F269_H275dup) and autopsy from normal pituitary glands without structural alterations. Cellular levels of pAMPK were significantly higher in patients with sporadic acromegaly compared to normal pituitary glands (p 
ISSN:0303-7207
1872-8057
1872-8057
DOI:10.1016/j.mce.2024.112318