Microbial production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate), from lab to the shelf: A review

Polyhydroxyalkanoates (PHAs) are natural biopolyesters produced by microorganisms that represent one of the most promising candidates for the replacement of conventional plastics due to their complete biodegradability and advantageous material properties which can be modulated by varying their monom...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-08, Vol.274 (Pt 1), p.133157, Article 133157
Main Authors: Jo, Seo Young, Lim, Seo Hyun, Lee, Ji Yeon, Son, Jina, Choi, Jong-Il, Park, Si Jae
Format: Article
Language:English
Subjects:
Biopolyester
Metabolic engineering strategy
P(3HB-co-3HV)
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Summary:Polyhydroxyalkanoates (PHAs) are natural biopolyesters produced by microorganisms that represent one of the most promising candidates for the replacement of conventional plastics due to their complete biodegradability and advantageous material properties which can be modulated by varying their monomer composition. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] has received particular research attention because it can be synthesized based on the same microbial platform developed for poly(3-hydroxybutyrate) [P(3HB)] without much modification, with as high productivity as P(3HB). It also offers more useful mechanical and thermal properties than P(3HB), which broaden its application as a biocompatible and biodegradable polyester. However, a significant commercial disadvantage of P(3HB-co-3HV) is its rather high production cost, thus many studies have investigated the economical synthesis of P(3HB-co-3HV) from structurally related and unrelated carbon sources in both wild-type and recombinant microbial strains. A large number of metabolic engineering strategies have also been proposed to tune the monomer composition of P(3HB-co-3HV) and thus its material properties. In this review, recent metabolic engineering strategies designed for enhanced production of P(3HB-co-3HV) are discussed, along with their current status, limitations, and future perspectives. •P(3HB-co-3HV) is microbial polyester with biocompatibility and biodegradability.•The mechanical properties of P(3HB-co-3HV) can be modified by its monomer composition.•Various metabolic and process engineering strategies have been developed for efficient P(3HB-co-3HV) production.•P(3HB-co-3HV) is a promising alternative to the conventional plastics for diverse industrial applications.
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.133157