Perioperative transfusion study (PETS): Does a liberal transfusion protocol improve outcome in high‐risk cardiovascular patients undergoing non‐cardiac surgery? A randomised controlled pilot study

Background Small studies have shown that patients with advanced coronary artery disease might benefit from a more liberal blood transfusion strategy. The goal of this pilot study was to test the feasibility of a blood transfusion intervention in a group of vascular surgery patients who have elevated...

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Published in:Transfusion medicine (Oxford, England) England), 2024-10, Vol.34 (5), p.398-404
Main Authors: Ali, Samir, Roubos, Steven, Hoeks, Sanne E., Verbrugge, Serge J. C., Koopman‐van Gemert, Ankie W. M. M., Stolker, Robert Jan, Lier, Felix
Format: Article
Language:English
Subjects:
myocardial infarction
red blood cell transfusions
troponin
vascular surgery
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Summary:Background Small studies have shown that patients with advanced coronary artery disease might benefit from a more liberal blood transfusion strategy. The goal of this pilot study was to test the feasibility of a blood transfusion intervention in a group of vascular surgery patients who have elevated cardiac troponins in rest. Methods We conducted a single‐centre, randomised controlled pilot study. Patients with a preoperative elevated high‐sensitive troponin T undergoing non‐cardiac vascular surgery were randomised between a liberal transfusion regime (haemoglobin >10.4 g/dL) and a restrictive transfusion regime (haemoglobin 8.0–9.6 g/dL) during the first 3 days after surgery. The primary outcome was defined as a composite endpoint of all‐cause mortality, myocardial infarction or unscheduled coronary revascularization. Results In total 499 patients were screened; 92 were included and 50 patients were randomised. Postoperative haemoglobin was different between the intervention and control group; 10.6 versus 9.8, 10.4 versus 9.4, 10.9 versus 9.4 g/dL on day one, two and three respectively (p 
ISSN:0958-7578
1365-3148
1365-3148
DOI:10.1111/tme.13058