The Effect of Eicosapentaenoic and Docosahexaenoic Acid Supplementation on Coronary Artery Calcium Progression in Subjects With Diabetes and Coronary Artery Disease: A Secondary Analysis of a Randomized Trial

Higher coronary artery calcium (CAC) scores and progression of CAC are associated with higher mortality. We previously reported that subjects with coronary artery disease randomly allocated to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation or none had similar significant...

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Published in:The American journal of cardiology 2024-08, Vol.225, p.98-104
Main Authors: Asbeutah, Abdul Aziz, Daher, Ralph, Malik, Abdulaziz, Hariri, Essa, Alfaddagh, Abdulhamied, Elajami, Tarec K., Welty, Francine K.
Format: Article
Language:English
Subjects:
Arteriosclerosis
Blood pressure
CAC score
Calcification (ectopic)
Calcium
Cardiovascular disease
Cholesterol
Computed tomography
Coronary artery disease
coronary computed tomography
Coronary vessels
Diabetes
Diabetes mellitus
Disease control
Docosahexaenoic acid
Eicosapentaenoic acid
Fatty acids
Heart diseases
Mortality
Supplements
Triglycerides
Vein & artery diseases
Work stations
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Summary:Higher coronary artery calcium (CAC) scores and progression of CAC are associated with higher mortality. We previously reported that subjects with coronary artery disease randomly allocated to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation or none had similar significant increases in CAC score over 30 months. Whether these findings are influenced by diabetes status is unknown. A total of 242 subjects with coronary artery disease who were on statin therapy were randomly allocated to to 1.86 g EPA and 1.5 g DHA daily or none (control). The CAC score was measured at baseline and 30-month follow-up using noncontrast, cardiac computed tomography. A significant interaction term between diabetes status and treatment arm was noted in the prediction of the CAC score (p
ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2024.06.001