An assessment of the antihyperlipidemic ingredients of Qi Ge Decoction based on metabolomics combined with serum pharmacochemistry

This study aims to explore the pharmacological substance basis of Qi Ge Decoction (QG) in antihyperlipidemia through a combination of metabolomics and serum pharmacochemistry. We used ultra‐performance liquid chromatography quadrupole‐time‐of‐flight/MS (UPLC Q‐TOF/MS) to analyze and identify the che...

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Bibliographic Details
Published in:Biomedical chromatography 2024-08, Vol.38 (8), p.e5922-n/a
Main Authors: Tang, Hui, Guo, Kai Xin, Huang, Ke Er, Li, Yan Fang, Chen, Wei, Wei, Hao Yang, Yu, Xiao Qing, Ke, Xue Hong
Format: Article
Language:English
Subjects:
constituents absorbed into the blood
effective substances
hyperlipidemia
metabolomics
Qi Ge decoction
UPLC Q‐TOF/MS
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Summary:This study aims to explore the pharmacological substance basis of Qi Ge Decoction (QG) in antihyperlipidemia through a combination of metabolomics and serum pharmacochemistry. We used ultra‐performance liquid chromatography quadrupole‐time‐of‐flight/MS (UPLC Q‐TOF/MS) to analyze and identify the chemical constituents of QG in vitro and in blood chemical components. The metabolomics technology was used to analyze serum biomarkers of QG in preventing and treating hyperlipidemia. We constructed a mathematical model of the relationship between constituents absorbed into the blood and endogenous biomarkers and explored the potential therapeutic application of QG for the prevention and treatment of hyperlipidemia. Compared with the model group, the levels of total cholesterol and triglyceride in the QG group were significantly decreased (P 
ISSN:0269-3879
1099-0801
1099-0801
DOI:10.1002/bmc.5922