Association of antibiotics with the outcomes in COVID-19 pneumonia patients with elevated PCT levels

To assess antibiotics impact on outcomes in COVID-19 pneumonia patients with varying procalcitonin (PCT) levels. This retrospective cohort study included 3665 COVID-19 pneumonia patients hospitalized at five Mayo Clinic sites (March 2020 to June 2022). PCT levels were measured at admission. Patients...

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Published in:Respiratory medicine 2024-09, Vol.231, p.107697, Article 107697
Main Authors: Raavi, Lekhya, Isha, Shahin, Jonna, Sadhana, Craver, Emily C., Nataraja, Hrishikesh, Jenkins, Anna, Hanson, Abby J., Venkataraman, Arvind Bala, Balasubramanian, Prasanth, Tekin, Aysun, Bansal, Vikas, Caples, Sean M., Khan, Syed Anjum, Jain, Nitesh K., LaNou, Abigail T., Kashyap, Rahul, Cartin-Ceba, Rodrigo, Patel, Bhavesh M., Milian, Ricardo Diaz, Venegas, Carla P., Shapiro, Anna B., Bhattacharyya, Anirban, Chaudhary, Sanjay, Kiley, Sean P., Erben, Young M., Quinones, Quintin J., Patel, Neal M., Guru, Pramod K., Franco, Pablo Moreno, Roy, Archana, Sanghavi, Devang K.
Format: Article
Language:English
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Summary:To assess antibiotics impact on outcomes in COVID-19 pneumonia patients with varying procalcitonin (PCT) levels. This retrospective cohort study included 3665 COVID-19 pneumonia patients hospitalized at five Mayo Clinic sites (March 2020 to June 2022). PCT levels were measured at admission. Patients’ antibiotics use and outcomes were collected via the Society of Critical Care Medicine (SCCM) Viral Infection and Respiratory Illness Universal Study (VIRUS) registry. Patients were stratified into high and low PCT groups based on the first available PCT result. The distinction between high and low PCT was demarcated at both 0.25 ng/ml and 0.50 ng/ml. Our cohort consisted of 3665 patients admitted with COVID-19 pneumonia. The population was predominantly male, Caucasian and non-Hispanic. With the PCT cut-off of 0.25 ng/ml, 2375 (64.8 %) patients had a PCT level
ISSN:0954-6111
1532-3064
1532-3064
DOI:10.1016/j.rmed.2024.107697