Infection dynamics of subtype H9N2 low pathogenic avian influenza a virus in turkeys

While mammals can be infected by influenza A virus either sporadically or with well adapted lineages, aquatic birds are the natural reservoir of the pathogen. So far most of the knowledge on influenza virus dynamics was however gained on mammalian models. In this study, we infected turkeys using a l...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2024-08, Vol.596, p.110124-110124, Article 110124
Main Authors: Ducatez, Mariette F., Wang, Chengcheng, Yang, Jialiang, Zhao, Yulong, Foret-Lucas, Charlotte, Croville, Guillaume, Loupias, Josianne, Teillaud, Angélique, Peralta, Brigitte, Ghram, Abdeljelil, Guérin, Jean-Luc, Wan, Xiu-Feng
Format: Article
Language:English
Subjects:
Chicken
Infection dynamics
Influenza virus
SIR
Target cell limited model
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Summary:While mammals can be infected by influenza A virus either sporadically or with well adapted lineages, aquatic birds are the natural reservoir of the pathogen. So far most of the knowledge on influenza virus dynamics was however gained on mammalian models. In this study, we infected turkeys using a low pathogenic avian influenza virus and determined the infection dynamics with a target-cell limited model. Results showed that turkeys had a different set of infection characteristics, compared with humans and ponies. The viral clearance rates were similar between turkeys and ponies but higher than that in humans. The cell death rates and cell to cell transmission rates were similar between turkeys and humans but higher than those in ponies. Overall, this study indicated the variations of within-host dynamics of influenza infection in avian, humans, and other mammalian systems. •IAV infection dynamics in turkeys is determined with a target-cell limited model.•Within-host dynamics of IAV infection vary in avian, humans, and other mammals.•Viral clearance in turkeys and ponies are similar but higher than that in humans.•Cell death rate in turkeys and humans are similar but higher than those in ponies.•Turkeys and humans had similar cell-to-cell transmission rates, higher than ponies.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2024.110124