Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction: A Case Report

An 11-year-old boy developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD). He originally developed Ewing sarcoma and was treated with high-dose chemotherapy including doxorubicin. On admission, he had severe aphasia, and magnetic resonance imaging showed occlusio...

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Bibliographic Details
Published in:Internal Medicine 2024, pp.3755-24
Main Authors: Eto, Futoshi, Nezu, Tomohisa, Sakahara, Hideaki, Yamamoto, Yumiko, Aoki, Shiro, Shimomura, Maiko, Karakawa, Shuhei, Maruyama, Hirofumi
Format: Article
Language:English
Subjects:
anthracycline
cancer therapy-related cardiac dysfunction
intravenous thrombolysis
left ventricular thrombus
pediatric stroke
transthoracic echocardiography
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Summary:An 11-year-old boy developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD). He originally developed Ewing sarcoma and was treated with high-dose chemotherapy including doxorubicin. On admission, he had severe aphasia, and magnetic resonance imaging showed occlusion of the left middle cerebral artery M3 segment. Transthoracic echocardiography revealed severe left ventricular dysfunction and a mobile thrombus at the left ventricular apex. Intravenous thrombolysis was administered, and effective recanalization was achieved. The patient did not exhibit any neurological deficits during discharge. Reperfusion therapy for pediatric patients has not yet been established; however, it may be effective for CES secondary to CTRCD.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3755-24