Antitussive, Expectorant and Antipyretic Effect of the Ethanolic Extract of the Leaves of Momordica charantia L

The traditional use of the M. charantia L. plant to treat coughs, fever and expectoration is widely practiced in different cultures, but its effectiveness and safety still require scientific investigation. This study sought to perform a chemical analysis and evaluate the antitussive, expectorant and...

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Published in:Chemistry & biodiversity 2024-08, Vol.21 (8), p.e202400072-n/a
Main Authors: Feitosa Ribeiro, Tiago, Carvalho de Souza, Nathália Andrezza, Cícero de Lima Araújo, Tarcísio, Ferreira Macedo, Cícero André, Souza Silva, Fabrício, Oliveira Siqueira, Andressa, Modesto Nascimento Menezes, Pedro, Gomes de Melo, Camila, Rolim Neto, Pedro José, Gonçalves de Oliveira Junior, Raimundo, Douglas Melo Coutinho, Henrique, Raposo, António, Araújo Rolim, Larissa
Format: Article
Language:English
Subjects:
Analytical chemistry
Antipyretic
Antitussive
Astragalin
Bronchus
Chemical analysis
Citric acid
Cough
Expectorant
Fever
Flavonoids
Herbal medicine
Isoquercetin
Lavage
Leaves
Liquid chromatography
Momordica charantia
Phenols
Plant extracts
Rats
Toxicity
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Summary:The traditional use of the M. charantia L. plant to treat coughs, fever and expectoration is widely practiced in different cultures, but its effectiveness and safety still require scientific investigation. This study sought to perform a chemical analysis and evaluate the antitussive, expectorant and antipyretic effects of the ethanolic extract of M. charantia leaves (EEMc) in rats and mice. The EEMc was subjected to chemical analysis by HPLC‐DAD, revealing the presence of the flavonoids astragalin and isoquercetin. Acute oral toxicity in mice did not result in deaths, although changes in liver weight and stool consistency were observed. EEMc demonstrated an antitussive effect at doses of 100 and 300 mg/kg in mice subjected to cough induction by citric acid nebulization. Furthermore, it showed expectorant activity at a dose of 300 mg/kg, assessed based on the elimination of the phenol red marker in bronchoalveolar lavage. In the evaluation of antipyretic activity in rats, fever induced by Saccharomyces cerevisiae was reduced at all doses tested during the first hour after treatment. This innovative study identified the presence of astragalin and isoquercetin in EEMc and indicated that the extract has antitussive, expectorant and antipyretic properties. Therefore, EEMc presents itself as a promising option in herbal medicine for the treatment of respiratory symptoms and fever.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400072