The ECG abnormalities in persons with chronic disorders of consciousness

We aimed to investigate the electrocardiogram (ECG) features in persons with chronic disorders of consciousness (DOC, ≥ 29 days since injury, DSI) resulted from the most severe brain damages. The ECG data from 30 patients with chronic DOC and 18 healthy controls (HCs) were recorded during resting wa...

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Bibliographic Details
Published in:Medical & biological engineering & computing 2024-10, Vol.62 (10), p.3013-3023
Main Authors: Tan, Xiaodan, Luo, Minmin, Xiao, Qiuyi, Zheng, Xiaochun, Kang, Jiajia, Zha, Daogang, Xie, Qiuyou, Zhan, Chang’an A.
Format: Article
Language:English
Subjects:
Abnormalities
Amplitudes
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Brain damage
Brain injury
Computer Applications
Consciousness
Disorders
EKG
Electrocardiography
Heart rate
Human Physiology
Imaging
Original Article
Radiology
Regression analysis
Sleep and wakefulness
Subgroups
Wakefulness
Waveforms
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Summary:We aimed to investigate the electrocardiogram (ECG) features in persons with chronic disorders of consciousness (DOC, ≥ 29 days since injury, DSI) resulted from the most severe brain damages. The ECG data from 30 patients with chronic DOC and 18 healthy controls (HCs) were recorded during resting wakefulness state for about five minutes. The patients were classified into vegetative state (VS) and minimally conscious state (MCS). Eight ECG metrics were extracted for comparisons between the subject subgroups, and regression analysis of the metrics were conducted on the DSI (29–593 days). The DOC patients exhibit a significantly higher heart rate (HR, p  = 0.009) and lower values for SDNN ( p  = 0.001), CVRR ( p  = 0.009), and T-wave amplitude ( p   0.05). Three ECG metrics of the DOC patients—HR, SDNN, and CVRR—are significantly correlated with the DSI. The ECG abnormalities persist in chronic DOC patients. The abnormalities are mainly manifested in the rhythm features HR, SDNN and CVRR, but not the waveform features such as QRS width, QT, QTc, ST and T-wave amplitudes. Graphical Abstract The abnormal cardiac rhythmic features (heart rate, HR, and heart rate variability, HRV) are found to persist in long-term (measured after 29 ~ 593 days since injury, DSI) in patients with disorders of consciousness (DOC). HR and HRV are respectively negatively and positively related to DSI. These findings have important implications on DOC patient management.
ISSN:0140-0118
1741-0444
1741-0444
DOI:10.1007/s11517-024-03129-5