Current use of estrogen-containing oral contraceptives or hormone therapy and risk of COVID-19 infection and hospitalization: a population-based cohort study

This population-based cohort study evaluated the association between current use of oral contraceptives (OC) among women under 50 years (n=306,541), and hormone therapy (HT) among women aged 50 or older (n=323,203), and COVID-19 infection and hospitalization. Current OC/HT use was recorded monthly u...

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Bibliographic Details
Published in:American journal of epidemiology 2024-05
Main Authors: Harrington, Laura B, Powers, J David, Bayliss, Elizabeth A, Fortmann, Stephen P, Shortreed, Susan M, Walker, Rod L, Floyd, James S, Kuntz, Jennifer, Fuller, Sharon, Albertson-Junkans, Ladia, Lee, Mi H, Temposky, Lisa A, Dublin, Sascha
Format: Article
Language:English
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Summary:This population-based cohort study evaluated the association between current use of oral contraceptives (OC) among women under 50 years (n=306,541), and hormone therapy (HT) among women aged 50 or older (n=323,203), and COVID-19 infection and hospitalization. Current OC/HT use was recorded monthly using prescription dispensing data. COVID-19 infections were identified March 2020-February 2021. COVID-19 infection and hospitalization were identified through diagnosis codes and laboratory tests. Weighted generalized estimating equations models estimated multivariable-adjusted odds ratios (aORs) for COVID-19 infection associated with time-varying OC/HT use. Among women with COVID-19, logistic regression models evaluated OC/HT use and COVID-19 hospitalization. Over 12 months, 11,727 (3.8%) women
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwae066