Thymic carcinoma presenting with overlap polyarthritis and myositis: A rare paraneoplastic syndrome in childhood

Thymic tumors are very rare neoplasms in children and account for less than 1% of mediastinal tumors in pediatric patients. One‐third of the pediatric patients present with symptoms related to the compression of the tumor mass on the surrounding anatomic structures, and paraneoplastic syndromes such...

Full description

Saved in:
Bibliographic Details
Published in:International journal of rheumatic diseases 2024-05, Vol.27 (5), p.e15187-n/a
Main Authors: Yıldız, Çisem, Türkcan, Büşra Topuz, Vural, Özge, Gezgin Yıldırım, Deniz, İnan, Mehmet Arda, Poyraz, Aylar, Pınarlı, Faruk Güçlü, Taştepe, İrfan, Demir, Ercan, Sunar Yayla, Emine Nur, Esmeray Şenol, Pelin, Karaçayır, Nihal, Bakkaloğlu, Sevcan A.
Format: Article
Language:English
Subjects:
Adolescent
Aplasia
arthritis
Arthritis - diagnosis
Arthritis - etiology
Biopsy
Carcinoma
Case reports
Children
Connective tissue diseases
Humans
Hypogammaglobulinemia
Male
Malignancy
Myasthenia gravis
Myopathy
Myositis
Myositis - complications
Myositis - diagnosis
Neuromuscular junctions
Paraneoplastic syndrome
Paraneoplastic Syndromes - diagnosis
Paraneoplastic Syndromes - etiology
Pediatrics
Polyarthritis
Thymectomy
thymic carcinoma
Thymoma - complications
Thymoma - diagnosis
Thymus
Thymus Neoplasms - complications
Thymus Neoplasms - diagnosis
Treatment Outcome
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thymic tumors are very rare neoplasms in children and account for less than 1% of mediastinal tumors in pediatric patients. One‐third of the pediatric patients present with symptoms related to the compression of the tumor mass on the surrounding anatomic structures, and paraneoplastic syndromes such as myasthenia gravis, pure red cell aplasia, acquired hypogammaglobulinemia, and connective tissue disorders, which rarely occur in children with thymic tumors. Herein, we report a case of thymic carcinoma mimicking the symptoms of a connective tissue disease with symmetrical polyarthritis accompanying myositis, fever, weight loss, and malaise in a 15‐year‐old male patient. To our knowledge, this is the first case pediatric thymic carcinoma accompany with severe polyarthritis and myopathy, thus we have reviewed the current literature regarding the cases of thymic malignancies coexisting with paraneoplastic syndromes in children.
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.15187