Are oral cancers effectively palliated with radiotherapy? Outcomes of treatment with a modified QUAD SHOT regimen

Background This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. Methods Retrospective data of 116 patients treated with a daily dose of 3.6–3.7 Gy in four fractions over 4 days...

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Bibliographic Details
Published in:Head & neck 2024-06, Vol.46 (6), p.1270-1279
Main Authors: Saha, Saheli, Mallick, Indranil, Mukherjee, Prattusha, Chakraborty, Santam, Bhattacharyya, Tapesh, S, Moses Arunsingh, Achari, Rimpa Basu, Chatterjee, Sanjoy
Format: Article
Language:English
Subjects:
Adult
advanced oral cancer
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - therapy
Dose Fractionation, Radiation
Female
Head & neck cancer
Head and neck
head and neck cancer
Humans
hypofractionated radiotherapy
Male
Middle Aged
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Mouth Neoplasms - radiotherapy
Mouth Neoplasms - therapy
Oral cancer
Palliation
Palliative Care - methods
palliative radiotherapy
QUAD SHOT
Radiation therapy
Retrospective Studies
Survival
Treatment Outcome
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Summary:Background This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. Methods Retrospective data of 116 patients treated with a daily dose of 3.6–3.7 Gy in four fractions over 4 days to a total of three courses, with a 2‐week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer. Results Ninety‐nine (85%) completed three courses. Overall subjective response rate was 77%. Median overall survival and progression‐free survival were 12 months (95% confidence interval [CI]: 8–20) and 8 months (95% CI: 6–10), with numerically higher overall survival in oral cancer. The treatment was well tolerated, with no on‐treatment hospitalization or grade 3–4 toxicities. Conclusion The modified QUAD SHOT regimen is practical for palliation in head and neck cancers.
ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.27730