Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress

[Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chroni...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2024-09, Vol.1838, p.148994, Article 148994
Main Authors: Chindo, Ben A., Yakubu, Musa I., Jimoh, Abdulfatai A., Waziri, Peter M., Abdullahi, Idris, Ayuba, Godwin I., Becker, Axel
Format: Article
Language:English
Subjects:
Cognitive dysfunction
Depression
Ficus platyphylla
Neuronal cell degeneration
Oxidative stress
PTZ–kindling
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c315t-d7e123e3bd6ff0de47557f03a7fafa24d7c587743c2322f66e338ddce8f675e83
container_end_page
container_issue
container_start_page 148994
container_title Brain research
container_volume 1838
creator Chindo, Ben A.
Yakubu, Musa I.
Jimoh, Abdulfatai A.
Waziri, Peter M.
Abdullahi, Idris
Ayuba, Godwin I.
Becker, Axel
description [Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chronic epilepsy and associated comorbidities via modulation of oxidative stress. PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP. FP (50 and 100 mg/kg, p.o.) ameliorated seizure severity, neuronal cell degeneration, depressive behaviors, cognitive dysfunctions, and oxidative stress in rats kindled with PTZ (42.5 mg/kg, i.p.). The findings from this study give additional insights into the potential values of FP in the treatment of persistent epilepsy and major neuropsychiatric comorbidities via modulation of oxidative stress.
doi_str_mv 10.1016/j.brainres.2024.148994
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3053974330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899324002488</els_id><sourcerecordid>3053974330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-d7e123e3bd6ff0de47557f03a7fafa24d7c587743c2322f66e338ddce8f675e83</originalsourceid><addsrcrecordid>eNqFkc1u1TAQhS0Eope2r1B5ySa3TpzfHaiiP1IlNrC2HHuszsWxg-1EpCvegQXvx5Pg6rZsWY1mdM4czXyEXJRsX7KyvTzsxyDRBYj7ilX1vqz7YahfkV3Zd1XRVjV7TXaMsbbIc35C3sV4yC3nA3tLTngWDZyXO_L7GtUS6Wxl2uaHzVpJpbWwokwQaQR8XALkukLAtFHpNHWwBD_Cg1zRB2mp8pMPI2pMmC3o6AwubRYcJEhBPnoLf37--oZOW9A0yBRpXk8nr5ecit5Rb6j_gTo3a85K-ah4Rt4YaSOcP9dT8vX605er2-L-883d1cf7QvGySYXuoKw48FG3xjANddc0nWFcdkYaWdW6U03fdTVXFa8q07bAea-1gt60XQM9PyXvj3vn4L8vEJOYMCrIf3Dglyg4a_iQ_ZxlaXuUquBjDGDEHHCSYRMlE09QxEG8QBFPUMQRSjZePGcs4wT6n-2FQhZ8OAogX7oiBBEVglOgMYBKQnv8X8ZfNJ6oWQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3053974330</pqid></control><display><type>article</type><title>Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress</title><source>ScienceDirect Freedom Collection</source><creator>Chindo, Ben A. ; Yakubu, Musa I. ; Jimoh, Abdulfatai A. ; Waziri, Peter M. ; Abdullahi, Idris ; Ayuba, Godwin I. ; Becker, Axel</creator><creatorcontrib>Chindo, Ben A. ; Yakubu, Musa I. ; Jimoh, Abdulfatai A. ; Waziri, Peter M. ; Abdullahi, Idris ; Ayuba, Godwin I. ; Becker, Axel</creatorcontrib><description>[Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chronic epilepsy and associated comorbidities via modulation of oxidative stress. PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP. FP (50 and 100 mg/kg, p.o.) ameliorated seizure severity, neuronal cell degeneration, depressive behaviors, cognitive dysfunctions, and oxidative stress in rats kindled with PTZ (42.5 mg/kg, i.p.). The findings from this study give additional insights into the potential values of FP in the treatment of persistent epilepsy and major neuropsychiatric comorbidities via modulation of oxidative stress.</description><identifier>ISSN: 0006-8993</identifier><identifier>ISSN: 1872-6240</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2024.148994</identifier><identifier>PMID: 38729331</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cognitive dysfunction ; Depression ; Ficus platyphylla ; Neuronal cell degeneration ; Oxidative stress ; PTZ–kindling</subject><ispartof>Brain research, 2024-09, Vol.1838, p.148994, Article 148994</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-d7e123e3bd6ff0de47557f03a7fafa24d7c587743c2322f66e338ddce8f675e83</cites><orcidid>0000-0002-4869-9901 ; 0000-0003-4843-584X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38729331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chindo, Ben A.</creatorcontrib><creatorcontrib>Yakubu, Musa I.</creatorcontrib><creatorcontrib>Jimoh, Abdulfatai A.</creatorcontrib><creatorcontrib>Waziri, Peter M.</creatorcontrib><creatorcontrib>Abdullahi, Idris</creatorcontrib><creatorcontrib>Ayuba, Godwin I.</creatorcontrib><creatorcontrib>Becker, Axel</creatorcontrib><title>Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>[Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chronic epilepsy and associated comorbidities via modulation of oxidative stress. PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP. FP (50 and 100 mg/kg, p.o.) ameliorated seizure severity, neuronal cell degeneration, depressive behaviors, cognitive dysfunctions, and oxidative stress in rats kindled with PTZ (42.5 mg/kg, i.p.). The findings from this study give additional insights into the potential values of FP in the treatment of persistent epilepsy and major neuropsychiatric comorbidities via modulation of oxidative stress.</description><subject>Cognitive dysfunction</subject><subject>Depression</subject><subject>Ficus platyphylla</subject><subject>Neuronal cell degeneration</subject><subject>Oxidative stress</subject><subject>PTZ–kindling</subject><issn>0006-8993</issn><issn>1872-6240</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1TAQhS0Eope2r1B5ySa3TpzfHaiiP1IlNrC2HHuszsWxg-1EpCvegQXvx5Pg6rZsWY1mdM4czXyEXJRsX7KyvTzsxyDRBYj7ilX1vqz7YahfkV3Zd1XRVjV7TXaMsbbIc35C3sV4yC3nA3tLTngWDZyXO_L7GtUS6Wxl2uaHzVpJpbWwokwQaQR8XALkukLAtFHpNHWwBD_Cg1zRB2mp8pMPI2pMmC3o6AwubRYcJEhBPnoLf37--oZOW9A0yBRpXk8nr5ecit5Rb6j_gTo3a85K-ah4Rt4YaSOcP9dT8vX605er2-L-883d1cf7QvGySYXuoKw48FG3xjANddc0nWFcdkYaWdW6U03fdTVXFa8q07bAea-1gt60XQM9PyXvj3vn4L8vEJOYMCrIf3Dglyg4a_iQ_ZxlaXuUquBjDGDEHHCSYRMlE09QxEG8QBFPUMQRSjZePGcs4wT6n-2FQhZ8OAogX7oiBBEVglOgMYBKQnv8X8ZfNJ6oWQ</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Chindo, Ben A.</creator><creator>Yakubu, Musa I.</creator><creator>Jimoh, Abdulfatai A.</creator><creator>Waziri, Peter M.</creator><creator>Abdullahi, Idris</creator><creator>Ayuba, Godwin I.</creator><creator>Becker, Axel</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4869-9901</orcidid><orcidid>https://orcid.org/0000-0003-4843-584X</orcidid></search><sort><creationdate>20240901</creationdate><title>Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress</title><author>Chindo, Ben A. ; Yakubu, Musa I. ; Jimoh, Abdulfatai A. ; Waziri, Peter M. ; Abdullahi, Idris ; Ayuba, Godwin I. ; Becker, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-d7e123e3bd6ff0de47557f03a7fafa24d7c587743c2322f66e338ddce8f675e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cognitive dysfunction</topic><topic>Depression</topic><topic>Ficus platyphylla</topic><topic>Neuronal cell degeneration</topic><topic>Oxidative stress</topic><topic>PTZ–kindling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chindo, Ben A.</creatorcontrib><creatorcontrib>Yakubu, Musa I.</creatorcontrib><creatorcontrib>Jimoh, Abdulfatai A.</creatorcontrib><creatorcontrib>Waziri, Peter M.</creatorcontrib><creatorcontrib>Abdullahi, Idris</creatorcontrib><creatorcontrib>Ayuba, Godwin I.</creatorcontrib><creatorcontrib>Becker, Axel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chindo, Ben A.</au><au>Yakubu, Musa I.</au><au>Jimoh, Abdulfatai A.</au><au>Waziri, Peter M.</au><au>Abdullahi, Idris</au><au>Ayuba, Godwin I.</au><au>Becker, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>1838</volume><spage>148994</spage><pages>148994-</pages><artnum>148994</artnum><issn>0006-8993</issn><issn>1872-6240</issn><eissn>1872-6240</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>[Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chronic epilepsy and associated comorbidities via modulation of oxidative stress. PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP. FP (50 and 100 mg/kg, p.o.) ameliorated seizure severity, neuronal cell degeneration, depressive behaviors, cognitive dysfunctions, and oxidative stress in rats kindled with PTZ (42.5 mg/kg, i.p.). The findings from this study give additional insights into the potential values of FP in the treatment of persistent epilepsy and major neuropsychiatric comorbidities via modulation of oxidative stress.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38729331</pmid><doi>10.1016/j.brainres.2024.148994</doi><orcidid>https://orcid.org/0000-0002-4869-9901</orcidid><orcidid>https://orcid.org/0000-0003-4843-584X</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0006-8993
ispartof Brain research, 2024-09, Vol.1838, p.148994, Article 148994
issn 0006-8993
1872-6240
1872-6240
language eng
recordid cdi_proquest_miscellaneous_3053974330
source ScienceDirect Freedom Collection
subjects Cognitive dysfunction
Depression
Ficus platyphylla
Neuronal cell degeneration
Oxidative stress
PTZ–kindling
title Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T06%3A36%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ficus%20platyphylla%20alleviates%20seizure%20severity%20and%20neurobehavioral%20comorbidities%20in%20pentylenetetrazole%E2%80%93kindled%20rats%20via%20modulation%20of%20oxidative%20stress&rft.jtitle=Brain%20research&rft.au=Chindo,%20Ben%20A.&rft.date=2024-09-01&rft.volume=1838&rft.spage=148994&rft.pages=148994-&rft.artnum=148994&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/j.brainres.2024.148994&rft_dat=%3Cproquest_cross%3E3053974330%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c315t-d7e123e3bd6ff0de47557f03a7fafa24d7c587743c2322f66e338ddce8f675e83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3053974330&rft_id=info:pmid/38729331&rfr_iscdi=true