Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole–kindled rats via modulation of oxidative stress

[Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chroni...

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Published in:Brain research 2024-09, Vol.1838, p.148994, Article 148994
Main Authors: Chindo, Ben A., Yakubu, Musa I., Jimoh, Abdulfatai A., Waziri, Peter M., Abdullahi, Idris, Ayuba, Godwin I., Becker, Axel
Format: Article
Language:English
Subjects:
Cognitive dysfunction
Depression
Ficus platyphylla
Neuronal cell degeneration
Oxidative stress
PTZ–kindling
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Summary:[Display omitted] •Preparations of Ficus platyphylla (FP) are used in traditional medicine to manage epilepsy.•FP ameliorated seizure severity, neuronal cell loss, depressive-like behaviors, cognitive deficits and oxidative stress in PTZ–kindled rats.•FP may be beneficial in the management of chronic epilepsy and associated comorbidities via modulation of oxidative stress. PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP. FP (50 and 100 mg/kg, p.o.) ameliorated seizure severity, neuronal cell degeneration, depressive behaviors, cognitive dysfunctions, and oxidative stress in rats kindled with PTZ (42.5 mg/kg, i.p.). The findings from this study give additional insights into the potential values of FP in the treatment of persistent epilepsy and major neuropsychiatric comorbidities via modulation of oxidative stress.
ISSN:0006-8993
1872-6240
1872-6240
DOI:10.1016/j.brainres.2024.148994