Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines

Combinatorial electrochemistry has great promise for accelerated reaction screening, organic synthesis, and catalysis. Recently, we described a new high-throughput electrochemistry platform, colloquially named “Legion”. Legion fits the footprint of a 96-well microtiter plate with simultaneous indivi...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2024-05, Vol.96 (21), p.8249-8253
Main Authors: Kulesa, Krista M., Hirtzel, Erin A., Nguyen, Vinh T., Freitas, Dallas P., Edwards, Madison E., Yan, Xin, Baker, Lane A.
Format: Article
Language:English
Subjects:
Azines
Benzophenone
Catalysis
Chemical synthesis
Combinatorial analysis
Electrochemical cells
Electrochemistry
Ionization
Mass spectrometry
Mass spectroscopy
Screening
Citations: Items that this one cites
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Summary:Combinatorial electrochemistry has great promise for accelerated reaction screening, organic synthesis, and catalysis. Recently, we described a new high-throughput electrochemistry platform, colloquially named “Legion”. Legion fits the footprint of a 96-well microtiter plate with simultaneous individual control over all 96 electrochemical cells. Here, we demonstrate the versatility of Legion when coupled with high-throughput mass spectrometry (MS) for electrosynthetic product screening and quantitation. Electrosynthesis of benzophenone azine was selected as a model reaction and was arrayed and optimized using a combination of Legion and nanoelectrospray ionization MS. The combination of high-throughput synthesis with Legion and analysis via MS proves a compelling strategy for accelerating reaction discovery and optimization in electro-organic synthesis.
ISSN:0003-2700
1520-6882
1520-6882
DOI:10.1021/acs.analchem.4c01110