Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common and deadly tumors of the central nervous system (CNS). The emergence of RNA therapies offers promise for the treatment of GBM. However, the efficient and precise delivery of RNA d...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2024-07, Vol.36 (29), p.e2401640-n/a
Main Authors: Zhu, Han, Wang, Yi‐Fan, Wang, Zhi‐Gang, Pang, Dai‐Wen, Liu, Shu‐Lin
Format: Article
Language:English
Subjects:
Blood-brain barrier
cell‐selective target
Central nervous system
Custom design
glioblastoma therapy
Glioma
Heterogeneity
lipid regulation of protein conformation
Lipids
Nanoparticles
Pathogenesis
Proteins
siRNA delivery
Tumors
virus‐mimicking nanoparticles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common and deadly tumors of the central nervous system (CNS). The emergence of RNA therapies offers promise for the treatment of GBM. However, the efficient and precise delivery of RNA drugs to specific tumor cells in the brain with high cellular heterogeneity remains ongoing. Here, a strategy is proposed to regulate protein conformation through lipid nanoenvironments to custom‐design virus‐mimicking nanoparticles (VMNs) with excellent selective cell targeting capabilities, leading to efficient and precise delivery of small interfering RNA for effective treatment of GBM. The optimized VMNs not only retain the ability to cross the blood–brain barrier and release the RNA by lysosomal escape like natural viruses but also ensure precise enrichment in the GBM area. This study lays the conceptual foundation for the custom design of VMNs with superior cell‐selective targeting capabilities and opens up the possibility of RNA therapies for the efficient treatment of GBM and CNS tumors. Here, a strategy is proposed to regulate protein conformation through lipid nanoenvironment to build virus‐mimicking nanoparticles (VMNs) for the efficient delivery of small interfering RNA, which have excellent cell‐selective targeting ability and retain the lysosomal escape properties of the virus, thus enabling the precise enrichment of VMNs in glioblastoma brain tumor region for efficient therapeutic purposes.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.202401640