Aberrant cortical morphology patterns are associated with cognitive impairment in patients with chronic heart failure

A mounting body of evidences suggests that patients with chronic heart failure (HF) frequently experience cognitive impairments, but the neuroanatomical mechanism underlying these impairments remains elusive. In this retrospective study, 49 chronic HF patients and 49 healthy controls (HCs) underwent...

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Bibliographic Details
Published in:The European journal of neuroscience 2024-07, Vol.60 (2), p.3973-3983
Main Authors: Liu, Yu Ting, Yang, Yu Ting, Tang, Chun Xiang, Ma, Jun Qing, Kong, Xiang, Li, Jian Hua, Li, Yan Ming, Liu, Shu Yu, Zhou, Chang Sheng, Wang, Yun Fei, Zhang, Long Jiang
Format: Article
Language:English
Subjects:
Anatomy
Autonomic nervous system
Brain architecture
Cardiovascular diseases
chronic heart failure
Cognition & reasoning
Cognitive ability
cognitive impairment
Congestive heart failure
cortical morphology
Heart failure
Morphology
Neuroimaging
Physical characteristics
Precentral gyrus
Risk factors
Sensorimotor system
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Summary:A mounting body of evidences suggests that patients with chronic heart failure (HF) frequently experience cognitive impairments, but the neuroanatomical mechanism underlying these impairments remains elusive. In this retrospective study, 49 chronic HF patients and 49 healthy controls (HCs) underwent brain structural MRI scans and cognitive assessments. Cortical morphology index (cortical thickness, complexity, sulcal depth and gyrification) were evaluated. Correlations between cortical morphology and cognitive scores and clinical variables were explored. Logistic regression analysis was employed to identify risk factors for predicting 3‐year major adverse cardiovascular events. Compared with HCs, patients with chronic HF exhibited decreased cognitive scores (p 
ISSN:0953-816X
1460-9568
1460-9568
DOI:10.1111/ejn.16382