Breast arterial calcification is associated with sarcopenia in peri- and post-menopausal women

Breast arterial calcification (BAC) refers to medial calcium deposition in breast arteries and is detectable via mammography. Sarcopenia, which is characterised by low skeletal muscle mass and quality, is associated with several serious clinical conditions, increased morbidity, and mortality. Both B...

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Bibliographic Details
Published in:Clinical imaging 2024-06, Vol.110, p.110143-110143, Article 110143
Main Authors: Erkan, Merve, Ozcan, Seray Gizem Gur
Format: Article
Language:English
Subjects:
Adult
Aged
Breast - blood supply
Breast - diagnostic imaging
Breast arterial calcification
Computed tomography
Cross-Sectional Studies
Female
Humans
Mammography
Mammography - methods
Middle Aged
Postmenopause
Sarcopenia
Sarcopenia - complications
Sarcopenia - diagnostic imaging
Tomography, X-Ray Computed - methods
Vascular Calcification - complications
Vascular Calcification - diagnostic imaging
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Summary:Breast arterial calcification (BAC) refers to medial calcium deposition in breast arteries and is detectable via mammography. Sarcopenia, which is characterised by low skeletal muscle mass and quality, is associated with several serious clinical conditions, increased morbidity, and mortality. Both BAC and sarcopenia share common pathologic pathways, including ageing, diabetes, and chronic kidney disease. Therefore, this study evaluated the relationship between BAC and sarcopenia as a potential indicator of sarcopenia. This study involved women aged >40. BAC was evaluated using digital mammography and was defined as vascular calcification. Sarcopenia was assessed using abdominal computed tomography. The cross-sectional skeletal mass area was measured at the third lumbar vertebra level. The skeletal mass index was obtained by dividing the skeletal mass area by height in square meters(m2). Sarcopenia was defined as a skeletal mass index of ≤38.5 cm2/m2. A multivariable model was used to evaluate the relationship between BAC and sarcopenia. The study involved 240 participants. Of these, 36 (15 %) were patients with BAC and 204 (85 %) were without BAC. Sarcopenia was significantly higher among the patients with BAC than in those without BAC (72.2 % vs 17.2 %, P 
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2024.110143