A comprehensive review of miR-21 in liver disease: Big impact of little things

[Display omitted] •miR-21 is a significant non-invasive biomarker for diagnosis, prediction, and prognosis in liver diseases.•miR-21 affects many biological processes in chronic liver diseases, including glycolipid metabolism, hepatotropic virus infection, inflammation and immune cell activation, he...

Full description

Saved in:
Bibliographic Details
Published in:International immunopharmacology 2024-06, Vol.134, p.112116, Article 112116
Main Authors: Xue, Xinyan, Li, Yanzhi, Yao, Yuxin, Zhang, Shenglin, Peng, Cheng, Li, Yunxia
Format: Article
Language:English
Subjects:
Animals
Biomarker
Biomarkers
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - immunology
Chronic liver disease
Hepatocellular carcinoma
Humans
Liver Diseases - genetics
Liver Neoplasms - genetics
Liver Neoplasms - immunology
Liver Neoplasms - therapy
MicroRNAs - genetics
miR-21
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •miR-21 is a significant non-invasive biomarker for diagnosis, prediction, and prognosis in liver diseases.•miR-21 affects many biological processes in chronic liver diseases, including glycolipid metabolism, hepatotropic virus infection, inflammation and immune cell activation, hepatic stellate cells activation and tissue fibrosis, and autophagy.•miR-21 is a liaison in the deterioration of chronic liver disease to hepatocellular carcinoma (HCC).•In the development of HCC, miR-21 not only affects the proliferation, apoptosis, epithelial mesenchymal transition, and immune escape of hepatoma cells, but also participates in intercellular crosstalk. microRNAs (miRNAs), a class of non-coding RNA with 20–24 nucleotides, are defined as the powerful regulators for gene expression. miR-21 is a multifunctional miRNA enriched in the circulatory system and multiple organs, which not only serves as a non-invasive biomarker in disease diagnosis, but also participates in many cellular activities. In various chronic liver diseases, the increase of miR-21 affects glycolipid metabolism, viral infection, inflammatory and immune cell activation, hepatic stellate cells activation and tissue fibrosis, and autophagy. Moreover, miR-21 is also a liaison in the deterioration of chronic liver disease to hepatocellular carcinoma (HCC), and it impacts on cell proliferation, apoptosis, migration, invasion, angiogenesis, immune escape, and epithelial-mesenchymal transformation by regulating target genes expression in different signaling pathways. In current research on miRNA therapy, some natural products can exert the hepatoprotective effects depending on the inhibition of miR-21 expression. In addition, miR-21-based therapeutic also play a role in regulating intracellular miR-21 levels and enhancing the efficacy of chemotherapy drugs. Herein, we systemically summarized the recent progress of miR-21 on biosynthesis, biomarker function, molecular mechanism and miRNA therapy in chronic liver disease and HCC, and looked forward to outputting some information to enable it from bench to bedside.
ISSN:1567-5769
1878-1705
1878-1705
DOI:10.1016/j.intimp.2024.112116