Clinical predictors of significant findings on EUS for the evaluation of incidental common bile duct dilation

Although EUS is highly accurate for the evaluation of common bile duct (CBD) dilation, the yield of EUS in patients with incidental CBD dilation is unclear. Serial patients undergoing EUS for incidental, dilated CBD (per radiologist, minimum of >6 mm objectively) from 2 academic medical centers w...

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Published in:Gastrointestinal endoscopy 2024-04
Main Authors: Raza, Zain, Altayar, Osama, Mahmoud, Tala, Abusaleh, Rami, Ghazi, Rabih, Early, Dayna, Kushnir, Vladimir M., Lang, Gabriel, Sloan, Ian, Hollander, Thomas, Rajan, Elizabeth, Storm, Andrew C., Abu Dayyeh, Barham K., Chandrasekhara, Vinay, Das, Koushik K.
Format: Article
Language:English
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Summary:Although EUS is highly accurate for the evaluation of common bile duct (CBD) dilation, the yield of EUS in patients with incidental CBD dilation is unclear. Serial patients undergoing EUS for incidental, dilated CBD (per radiologist, minimum of >6 mm objectively) from 2 academic medical centers without active pancreaticobiliary disease or significantly elevated liver function test results were evaluated. Multivariable logistic regression identified predictors of EUS with significant findings and a novel prediction model was derived from one center, internally validated with bootstrapping, and externally validated at the second center. Of 375 patients evaluated, 31 (8.3%) had significant findings, including 26 choledocholithiasis, 1 ampullary adenoma, and 1 pancreatic mass. Predictors of significant findings with EUS included age of ≥70 years (odds ratio [OR], 3.7; 95% confidence interval [CI], 1.5-10.0), non–biliary-type abdominal pain without chronic pain (OR, 6.1; 95% CI, 2.3-17.3), CBD diameter of ≥15 mm or ≥17 mm with cholecystectomy (OR, 6.9; 95% CI, 2.7-18.7), and prior ERCP (OR, 6.8; 95% CI, 2.1-22.5). A point-based novel clinical prediction model was created: age of ≥70 years = 1, non–biliary-type abdominal pain without chronic pain = 2, prior ERCP = 2, and CBD dilation = 2. A score of 
ISSN:0016-5107
1097-6779
1097-6779
DOI:10.1016/j.gie.2024.04.2902