Anti-Anisakis antibodies in colon cancer patients and their relationship with γδ T-cells

Many pathogens are related to carcinogenesis. Chronic inflammation, as a result of persistent infection, leads to DNA damage, higher expression of oncogenes, decreased apoptosis and immunosuppression, which are some of the reasons for cancer induction. Among parasites, Schistosoma , Opistorchis and...

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Published in:Parasitology research (1987) 2024-04, Vol.123 (4), p.196-196, Article 196
Main Authors: Andreu-Ballester, Juan C., Cuéllar, Carmen, Colmena-Zaragoza, Javier, Galindo-Regal, Lorena, Hurtado-Marcos, Carolina, González-Fernández, Juan, Balciscueta, Zutoia, García-Ballesteros, Carlos, López-Chuliá, Francisca, Jiménez, Ana I., Llombart-Cussac, Antonio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Animals
Anisakis
Anisakis - immunology
Antibodies
Antibodies, Helminth - blood
Antibodies, Helminth - immunology
Apoptosis
Biomedical and Life Sciences
Biomedicine
Carcinogenesis
CD3 antigen
CD4 antigen
CD8 antigen
Chronic infection
Colon cancer
Colonic Neoplasms - immunology
Colonic Neoplasms - parasitology
Colorectal cancer
DNA damage
Female
Humans
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunology
Immunosuppression
Inflammation
Lymphocytes T
Male
Medical Microbiology
Microbiology
Middle Aged
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocyte Subsets - immunology
T-Lymphocytes - immunology
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Summary:Many pathogens are related to carcinogenesis. Chronic inflammation, as a result of persistent infection, leads to DNA damage, higher expression of oncogenes, decreased apoptosis and immunosuppression, which are some of the reasons for cancer induction. Among parasites, Schistosoma , Opistorchis and Clonorchis are recognised as infectious agents which contribute to cancer. A relationship between Anisakis and cancer was hypothesised because cellular responses to Anisakis products could result in inflammation and DNA damage. Previous research has shown a decrease in CD8+ γδ T-cells and an increase in αβ and γδ T-cell apoptosis in colon cancer (CC) samples. Ninety-two CC patients and 60 healthy subjects were recruited. γδ and αβ T-cells were analysed, and their apoptosis was evaluated. Anti- Anisakis antibodies were tested in sera from CC patients and controls. Anti- Anisakis IgG, IgM, IgA and IgE antibodies were significantly higher in CC patients. A significant increase in anti- Anisakis IgA levels was observed in patients with angiolymphatic invasion. The number of all γδ T-cells, as well as CD3+ CD4+ αβ T-cells, was significantly lower in CC patients. The apoptosis of all T-cells was significantly increased in patients with CC. We observed a significantly higher percentage of anti- Anisakis IgE positive patients having a deficit of CD3+ γδ T-cells. Our results suggest a relationship between Anisakis and CC.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-024-08216-y