Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium

There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association be...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2024-09, Vol.155 (5), p.854-870
Main Authors: Ho, Nhan Thi, Abe, Sarah Krull, Rahman, Md. Shafiur, Islam, Rashedul, Saito, Eiko, Gupta, Prakash C., Pednekar, Mangesh S., Sawada, Norie, Tsugane, Shoichiro, Tamakoshi, Akiko, Kimura, Takashi, Shu, Xiao‐Ou, Gao, Yu‐Tang, Koh, Woon‐Puay, Cai, Hui, Wen, Wanqing, Sakata, Ritsu, Tsuji, Ichiro, Malekzadeh, Reza, Pourshams, Akram, Kanemura, Seiki, Kim, Jeongseon, Chen, Yu, Ito, Hidemi, Oze, Isao, Nagata, Chisato, Wada, Keiko, Sugawara, Yumi, Park, Sue K., Shin, Aesun, Yuan, Jian‐Min, Wang, Renwei, Kweon, Sun‐Seog, Shin, Min‐Ho, Poustchi, Hossein, Vardanjani, Hossein Molavi, Ahsan, Habibul, Chia, Kee Seng, Matsuo, Keitaro, Qiao, You‐Lin, Rothman, Nathaniel, Zheng, Wei, Inoue, Manami, Kang, Daehee, Boffetta, Paolo
Format: Article
Language:English
Subjects:
Alcohol use
Asia Cohort Consortium
Asian people
Body mass index
Chronic illnesses
Consortia
Diabetes
Diabetes mellitus
Epidemiology
Health risks
incidence
Liver cancer
Medical diagnosis
Meta-analysis
Mortality
Population studies
Public health
Tobacco
Tobacco smoking
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two‐stage meta‐analysis across studies was also done. There were 839,194 subjects with valid data regarding liver cancer incidence (5654 liver cancer cases [48.29/100,000 person‐years]), follow‐up time and baseline diabetes (44,781 with diabetes [5.3%]). There were 747,198 subjects with valid data regarding liver cancer mortality (5020 liver cancer deaths [44.03/100,000 person‐years]), follow‐up time and baseline diabetes (43,243 with diabetes [5.8%]). Hazard ratio (HR) (95% confidence interval [95%CI]) of liver cancer diagnosis in those with vs. without baseline diabetes was 1.97 (1.79, 2.16) (p 
ISSN:0020-7136
1097-0215
1097-0215
DOI:10.1002/ijc.34965