Comparison of porcine versus bovine surfactant in preterm respiratory distress syndrome: Evidence from real‐world data. A multicentre collaboration from Karnataka

Background & Objectives Porcine surfactant (200 mg/kg initial dose) seems to be superior to bovine surfactants (100 mg/kg) in respiratory distress syndrome (RDS). There is limited data on the choice of surfactant from the developing world. Logically, using higher doses of porcine surfactant come...

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Published in:Pediatric pulmonology 2024-07, Vol.59 (7), p.1979-1986
Main Authors: Aradhya, Abhishek S., Ghalige, Sharath S., Madarkar, Babu, Pruthvishree, Hodali Venkataramananaidu, Venkatagiri, Praveen, Urs, Prashant, Ngangom, Daizy, Rangaiah, Sandeep, Kumar, Vimal, Harini, Chinnaraja, Bansal, Arpna, Halkar, Maneesha P.
Format: Article
Language:English
Subjects:
chronic lung disease
Continuous positive airway pressure
preterm
RDS
Respiratory distress syndrome
surfactant types
Surfactants
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Summary:Background & Objectives Porcine surfactant (200 mg/kg initial dose) seems to be superior to bovine surfactants (100 mg/kg) in respiratory distress syndrome (RDS). There is limited data on the choice of surfactant from the developing world. Logically, using higher doses of porcine surfactant comes with an additional cost burden. We decided to evaluate the clinical effects of different types of surfactants. Methods A retrospective analysis was conducted from August 2019 to December 2022 in six tertiary centers. Neonates 24–34 weeks of gestation with RDS requiring either porcine (200 mg/kg) or bovine surfactant (100 mg/kg) were enrolled. The proportion of BPD, redosing, and other morbidities in either group were analyzed. The outcomes in preterm ≥28 and
ISSN:8755-6863
1099-0496
1099-0496
DOI:10.1002/ppul.27032