Endurance exercise associated with a fructooligosaccharide diet modulates gut microbiota and increases colon absorptive area

Background and Aim Fructooligosaccharide (FOS) supplementation can stimulate beneficial intestinal bacteria growth, but little is known about its influence on training performance. Therefore, this study analyzed FOS and exercise effects on gut microbiota and intestinal morphology of C57Bl/6 mice. Me...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2024-06, Vol.39 (6), p.1145-1154
Main Authors: Moura, Filipe, Romeiro, Caroline, Petriz, Bernardo, Cavichiolli, Nathalia, Almeida, Jeeser A., Castro, Alinne, Franco, Octavio L.
Format: Article
Language:English
Subjects:
absorptive area
colon
Diet
Digestive system
Digestive tract
endurance exercise
Exercise
Fructooligosaccharides
gut microbiota
Intestinal microflora
Intestine
Microbiota
oligosaccharides
Physical fitness
Physical training
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Summary:Background and Aim Fructooligosaccharide (FOS) supplementation can stimulate beneficial intestinal bacteria growth, but little is known about its influence on training performance. Therefore, this study analyzed FOS and exercise effects on gut microbiota and intestinal morphology of C57Bl/6 mice. Methods Forty male mice were divided into four groups: standard diet‐sedentary (SDS), standard diet‐exercised (SDE), FOS supplemented (7.5% FOS)‐sedentary (FDS), and FOS supplemented‐exercised (FDE), n = 10 each group. Exercise training consisted of 60 min/day, 3 days/week, for 12 weeks. Results SDE and FDE groups had an increase in aerobic performance compared to the pretraining period and SDS and FDS groups (P < 0.01), respectively. Groups with FOS increased colonic crypts size (P < 0.05). The FDE group presented rich microbiota (α‐diversity) compared to other groups. The FDE group also acquired a greater microbial abundance (β‐diversity) than other groups. The FDE group had a decrease in the Ruminococcaceae (P < 0.002) and an increase in Roseburia (P < 0.003), Enterorhabdus (P < 0.004) and Anaerotruncus (P < 0.006). Conclusions These findings suggest that aerobic exercise associated with FOS supplementation modulates gut microbiota and can increase colonic crypt size without improving endurance exercise performance.
ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.16563