Independent Relationship of Lipoprotein(a) and Carotid Atherosclerosis With Long-Term Risk of Cardiovascular Disease

Lipoprotein(a) (Lp(a)) is considered to be a causal risk factor of atherosclerotic cardiovascular disease (ASCVD), but whether there is an independent or joint association of Lp(a) and atherosclerotic plaque with ASCVD risk remains uncertain. This study aims to assess ASCVD risk independently or joi...

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Bibliographic Details
Published in:	Journal of the American Heart Association 2024-05, Vol.13 (9), p.e033488-e033488
Main Authors:	Qi, Yue, Duan, Youling, Deng, Qiuju, Yang, Na, Sun, Jiayi, Li, Jiangtao, Hu, Piaopiao, Liu, Jun, Liu, Jing
Format:	Article
Language:	eng
Subjects:	Aged atherosclerotic cardiovascular disease Biomarkers - blood Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Carotid Artery Diseases - blood Carotid Artery Diseases - epidemiology carotid atherosclerosis cohort study Female Heart Disease Risk Factors Humans Incidence Ischemic Stroke - blood Ischemic Stroke - epidemiology Ischemic Stroke - etiology lipoprotein(a) Lipoprotein(a) - blood Male Middle Aged Plaque, Atherosclerotic - epidemiology Risk Assessment Risk Factors Time Factors
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Summary:	Lipoprotein(a) (Lp(a)) is considered to be a causal risk factor of atherosclerotic cardiovascular disease (ASCVD), but whether there is an independent or joint association of Lp(a) and atherosclerotic plaque with ASCVD risk remains uncertain. This study aims to assess ASCVD risk independently or jointly conferred by Lp(a) and carotid atherosclerotic plaque. A total of 5471 participants with no history of cardiovascular disease at baseline were recruited and followed up for ASCVD events (all fatal and nonfatal acute coronary and ischemic stroke events) over a median of 11.5 years. Independent association of Lp(a), or the joint association of Lp(a) and carotid plaque with ASCVD risk, was explored using Cox proportional hazards models. Overall, 7.6% of the participants (60.0±7.9 years of age; 2649 [48.4%] men) had Lp(a) ≥50 mg/dL, and 539 (8.4/1000 person-years) incident ASCVD events occurred. Lp(a) concentrations were independently associated with long-term risk of total ASCVD events, as well as coronary events and ischemic stroke events. Participants with Lp(a) ≥50 mg/dL had a 62% higher risk of ASCVD incidence (95% CI, 1.19-2.21) than those with Lp(a)
ISSN:	2047-9980