Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer

•This study compared the changes of CCA IMT, carotid plaques number and volume before and after radiotherapy.•After radiotherapy, the CCA IMT, carotid plaques number and volume increased.•The radiation dose, age, and smoking had an effect on CCA IMT; Age, hypertension, and sex have an impact on the...

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Bibliographic Details
Published in:Radiotherapy and oncology 2024-07, Vol.196, p.110285, Article 110285
Main Authors: Zheng, Zhuangzhuang, Shen, Yingying, Su, Jing, Ji, Xiaorui, Zhang, Qiang, Zhao, Qin, Jiang, Xin
Format: Article
Language:English
Subjects:
Carotid artery plaque
Carotid intima-media thickness
Head and neck cancer
Radiotherapy
Ultrasound
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Summary:•This study compared the changes of CCA IMT, carotid plaques number and volume before and after radiotherapy.•After radiotherapy, the CCA IMT, carotid plaques number and volume increased.•The radiation dose, age, and smoking had an effect on CCA IMT; Age, hypertension, and sex have an impact on the number and volume of carotid plaques.•Correlation analysis, hierarchical regression analysis proved that radiation dose was a significant predictor of CCA IMT in RT patients. Radiotherapy (RT) can damage neck vessels in patients with head and neck cancer (HNC). This study investigated the early effects of RT on carotid artery, including the internal media thickness (IMT) and carotid plaques of the common carotid artery (CCA). This study included 69 patients with HNC who underwent RT at the First Hospital of Jilin University from March 2017 to September 2022, and 69 healthy participants as controls. Color Doppler ultrasound (CDUS) of the carotid artery was used to measure the CCA IMT and plaques. Left CCA IMT increased from 0.60 mm (0.60, 0.70) before RT to 0.70 mm (0.60, 1.20) after RT (P 40 Gy groups (P = 0.0004). The CCA plaques number increased significantly after RT on both the left and right sides (Pleft 
ISSN:0167-8140
1879-0887
1879-0887
DOI:10.1016/j.radonc.2024.110285